ID
Name
Class
Organism
Assay Summary
1
kalata B1
Cyclotide
Viola odorata Oldenlandia affinis Viola tricolor Hybanthus enneaspermus Viola baoshanensis Viola yedoensis Viola philippica Viola sumatrana Miq
Showed that kalata B1 and B6 would bind selectively to bacterial membranes. [...] Kalata B1 binds to DPC micelles. [...] Kalata B1 and B2 cause leakage of dye-containing POPC vesicles. [...]
4
kalata B2
Cyclotide
Viola odorata Oldenlandia affinis
Kalata B1 and B2 cause leakage of dye-containing POPC vesicles. [...]
21
cycloviolacin O2
Cyclotide
Viola odorata Hybanthus enneaspermus Viola baoshanensis Viola biflora Viola philippica Viola uliginosa Viola arcuata Viola austrosinensis Viola anagae
[I11L] mutants of cyO2, cyO9, hyen D and kalata B5 exhibited equipotent binding to the POPC/POPE(80:20) model membrane compared to their wild-type counterparts whereas the [I11G] mutants showed no binding or weak affinity to membranes. [...] Tb3+/DPA Liposome Assay on cycloviolacin O2 showed an effect within minutes [...]
24
kalata B6
Cyclotide
Oldenlandia affinis
Showed that kalata B1 and B6 would bind selectively to bacterial membranes. [...]
26
kalata B7
Cyclotide
Oldenlandia affinis Geophila repens
Kalata B7 binds to DPC micelles [...]
34
cycloviolacin O9
Cyclotide
Viola odorata Viola biflora
[I11L] mutants of cyO2, cyO9, hyen D and kalata B5 exhibited equipotent binding to the POPC/POPE(80:20) model membrane compared to their wild-type counterparts whereas the [I11G] mutants showed no binding or weak affinity to membranes. [...]
59
kalata B5
Cyclotide
Oldenlandia affinis
[I11L] mutants of cyO2, cyO9, hyen D and kalata B5 exhibited equipotent binding to the POPC/POPE(80:20) model membrane compared to their wild-type counterparts whereas the [I11G] mutants showed no binding or weak affinity to membranes. [...]
85
RTD-1
Primate
Macaca mulatta (rhesus monkey)
NMR used to investigate RTD-1 interaction with lipid bilayer [...] The cyclic antimicrobial peptide RTD-1 induces stabilized lipid-peptide domains more efficiently than its open-chain analogue [...] RTD-1 shows two physicacally distinct states when bound to lipid bilayers [...] RTD-1-3 shown to bind with equal affinity to E.coli. [...]
88
oRTD-1
Primate
Synthetic
The cyclic antimicrobial peptide RTD-1 induces stabilized lipid-peptide domains more efficiently than its open-chain analogue [...]
89
RTD-2
Primate
Macaca mulatta (rhesus monkey)
RTD-1-3 shown to bind with equal affinity to E.coli. [...]
90
RTD-3
Primate
Macaca mulatta (rhesus monkey)
RTD-1-3 shown to bind with equal affinity to E.coli. [...]
1139
hyen D
Cyclotide
Hybanthus enneaspermus
[I11L] mutants of cyO2, cyO9, hyen D and kalata B5 exhibited equipotent binding to the POPC/POPE(80:20) model membrane compared to their wild-type counterparts whereas the [I11G] mutants showed no binding or weak affinity to membranes. [...]
1935
[I11G]cyO2
Cyclotide
Synthetic
[I11L] mutants of cyO2, cyO9, hyen D and kalata B5 exhibited equipotent binding to the POPC/POPE(80:20) model membrane compared to their wild-type counterparts whereas the [I11G] mutants showed no binding or weak affinity to membranes. [...]
1936
[I11L]cyO2
Cyclotide
Synthetic
[I11L] mutants of cyO2, cyO9, hyen D and kalata B5 exhibited equipotent binding to the POPC/POPE(80:20) model membrane compared to their wild-type counterparts whereas the [I11G] mutants showed no binding or weak affinity to membranes. [...]
1937
[I11G]cyO9
Cyclotide
Synthetic
[I11L] mutants of cyO2, cyO9, hyen D and kalata B5 exhibited equipotent binding to the POPC/POPE(80:20) model membrane compared to their wild-type counterparts whereas the [I11G] mutants showed no binding or weak affinity to membranes. [...]
1938
[I11L]cyO9
Cyclotide
Synthetic
[I11L] mutants of cyO2, cyO9, hyen D and kalata B5 exhibited equipotent binding to the POPC/POPE(80:20) model membrane compared to their wild-type counterparts whereas the [I11G] mutants showed no binding or weak affinity to membranes. [...]
1939
[I11G]hyen D
Cyclotide
Synthetic
[I11L] mutants of cyO2, cyO9, hyen D and kalata B5 exhibited equipotent binding to the POPC/POPE(80:20) model membrane compared to their wild-type counterparts whereas the [I11G] mutants showed no binding or weak affinity to membranes. [...]
1940
[I11L]hyen D
Cyclotide
Synthetic
[I11L] mutants of cyO2, cyO9, hyen D and kalata B5 exhibited equipotent binding to the POPC/POPE(80:20) model membrane compared to their wild-type counterparts whereas the [I11G] mutants showed no binding or weak affinity to membranes. [...] Membrane binding affinity of the hyen D variants [...]
1941
[I11G]kB5
Cyclotide
Synthetic
[I11L] mutants of cyO2, cyO9, hyen D and kalata B5 exhibited equipotent binding to the POPC/POPE(80:20) model membrane compared to their wild-type counterparts whereas the [I11G] mutants showed no binding or weak affinity to membranes. [...]
1942
[I11L]kB5
Cyclotide
Synthetic
[I11L] mutants of cyO2, cyO9, hyen D and kalata B5 exhibited equipotent binding to the POPC/POPE(80:20) model membrane compared to their wild-type counterparts whereas the [I11G] mutants showed no binding or weak affinity to membranes. [...]
1944
[G1A, I11L]hyen D
Cyclotide
Synthetic
Membrane binding affinity of the hyen D variants [...]
1945
[F2A, I11L]hyen D
Cyclotide
Synthetic
Membrane binding affinity of the hyen D variants [...]
1946
[G5A, I11L]hyen D
Cyclotide
Synthetic
Membrane binding affinity of the hyen D variants [...]
1947
[S7A, I11L]hyen D
Cyclotide
Synthetic
Membrane binding affinity of the hyen D variants [...]
1948
[V9A, I11L]hyen D
Cyclotide
Synthetic
Membrane binding affinity of the hyen D variants [...]
1949
[Y10A, I11L]hyen D
Cyclotide
Synthetic
Membrane binding affinity of the hyen D variants [...]
1950
[I11A]hyen D
Cyclotide
Synthetic
Membrane binding affinity of the hyen D variants [...]
1951
[I11L, F14A]hyen D
Cyclotide
Synthetic
Membrane binding affinity of the hyen D variants [...]
1952
[I11L, I18A]hyen D
Cyclotide
Synthetic
Membrane binding affinity of the hyen D variants [...]
1953
[I11L, S21A]hyen D
Cyclotide
Synthetic
Membrane binding affinity of the hyen D variants [...]
1954
[I11L, K23A]hyen D
Cyclotide
Synthetic
Membrane binding affinity of the hyen D variants [...]
1955
[I11L, S24A]hyen D
Cyclotide
Synthetic
Membrane binding affinity of the hyen D variants [...]
1956
[I11L, K25A]hyen D
Cyclotide
Synthetic
Membrane binding affinity of the hyen D variants [...]
1957
[I11L, V26A]hyen D
Cyclotide
Synthetic
Membrane binding affinity of the hyen D variants [...]
1958
[I11L, Y28A]hyen D
Cyclotide
Synthetic
Membrane binding affinity of the hyen D variants [...]
1959
[I11L, K29A]hyen D
Cyclotide
Synthetic
Membrane binding affinity of the hyen D variants [...]
1960
[I11L, N30A]hyen D
Cyclotide
Synthetic
Membrane binding affinity of the hyen D variants [...]