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Reference List

The references are sorted by year then first author.
Each reference is followed by a 'P' link and a 'NA' link that search the corresponding protein sequences and nucleic acid sequences, respectively.

Found 359 entries.

References
2023 Rajendran,S., Slazak,B., Mohotti,S., Muhammad,T., Strömstedt,A.A., Kapusta,M., Wilmowicz,E., Göransson,U., Hettiarachchi,C.M., and Gunasekera,S. Screening for Cyclotides in Sri Lankan Medicinal Plants: Discovery, Characterization, and Bioactivity Screening of Cyclotides from Geophila repens. J Nat Prod (2023) 86: 52-65 [P, NA]
2022 Aslam,L., Kaur,R., Hussain,S., Kapoor,N., and Mahajan,R. LC-MS/MS identification and structural characterization of isolated cyclotides from precursor sequences of Viola odorata L. petiole tissue using computational approach. J Biosci (2022) 47: 50-0 [P, NA]
Dang,T.T., Harvey,P.J., Chan,L.Y., Huang,Y.-H., Kaas,Q., Craik,D.J. Mutagenesis of cyclotide Cter 27 exemplifies a robust folding strategy for bracelet cyclotides Peptide Science (2022) : 0-0 [P, NA]
Du,Q., Huang,Y.H., Wang,C.K. and Craik,D.J. Mutagenesis of bracelet cyclotide hyen D reveals functionally and structurally critical residues for membrane binding and cytotoxicity. J Biol Chem (2022) 298: 101822-0 [P, NA]
Fernández-Bobey,A., Pinto,M., de Almeida,L.C., de Souza,B.M., Dias,N.B., de Paula-Souza,J., Cilli,E.M., Lopes,N.P., Costa-Lotufo,L.V., Palma,M.S., and da Silva Bolzani,V. Cytotoxic Cyclotides from Anchietea pyrifolia, a South American Plant Species. J Nat Prod (2022) 85: 2127-2134 [P, NA]
Gerlach,S.L., Dunlop,R.A., Metcalf,J.S., Banack,S.A., and Cox,P.A. Cyclotides Chemosensitize Glioblastoma Cells to Temozolomide. J Nat Prod (2022) 85: 34-46 [P, NA]
Slazak, B., J?drzejska, A., Badyra,B., Shariatgorji,R., Nilsson,A., Andrén,P.E., and Göransson,U. The Influence of Plant Stress Hormones and Biotic Elicitors on Cyclotide Production in Viola uliginosa Cell Suspension Cultures. Plants (Basel) (2022) 11: 1876-0 [P, NA]
Taghizadeh,M.S., Retzl,B., Muratspahi?,E., Trenk,C., Casanova,E., Moghadam,A., Afsharifar,A., Niazi,A., and Gruber,C.W. Discovery of the cyclotide caripe 11 as a ligand of the cholecystokinin-2 receptor. Sci Rep (2022) 12: 9215-0 [P, NA]
Tian, S., Durek, T., Wang, C.K., Zdenek, C.N., Fry, B.G., Craik, D.J., and de Veer, S.J. Engineering the Cyclization Loop of MCoTI-II Generates Targeted Cyclotides that Potently Inhibit Factor XIIa. J Med Chem (2022) 65: 15698-15709 [P, NA]
2021 Aslam,L., Kaur,R., Sharma,V., Kapoor,N. and Mahajan,R. Isolation and characterization of cyclotides from the leaves of Viola odorata L. using peptidomic and bioinformatic approach. 3 Biotech (2021) 11: 211-0 [P, NA]
Dang,T.T., Chan,L.Y., Tombling,B.J., Harvey,P.J., Gilding,E.K. and Craik,D.J. In Planta Discovery and Chemical Synthesis of Bracelet Cystine Knot Peptides from Rinorea bengalensis. J Nat Prod (2021) 84: 395-407 [P, NA]
Gattringer J, Ndogo OE, Retzl B, Ebermann C, Gruber CW, Hellinger R. Cyclotides Isolated From Violet Plants of Cameroon Are Inhibitors of Human Prolyl Oligopeptidase. Front Pharmacol (2021) 12: 707596-0 [P, NA]
Hellinger,R., Muratspahi?,E., Devi,S., Koehbach,J., Vasileva,M., Harvey,P.J., Craik,D.J. and Gruber,C.W. Importance of the Cyclic Cystine Knot Structural Motif for Immunosuppressive Effects of Cyclotides. ACS Chem Biol (2021) 16: 2373-2386 [P, NA]
Huang,Y.H., Du,Q., Jiang,Z., King,G.J., Collins,B.M. and Craik,D.J. Enabling Efficient Folding and High-Resolution Crystallographic Analysis of Bracelet Cyclotides. Molecules (2021) 26: 0-0 [P, NA]
Liu W, de Veer SJ, Huang YH, Sengoku T, Okada C, Ogata K, Zdenek CN, Fry BG, Swedberg JE, Passioura T, Craik DJ, Suga H. An Ultrapotent and Selective Cyclic Peptide Inhibitor of Human beta-Factor XIIa in a Cyclotide Scaffold J Am Chem Soc (2021) 143: 18481-18489 [P, NA]
Payne,C.D., Franke,B., Fisher,M.F., Hajiaghaalipour,F., McAleese,C.E., Song,A., Eliasson,C., Zhang,J., Jayasena, A.S., Vadlamani,G., Clark,R.J., Minchin,R.F., Mylne,J.S., Rosengren,K.J. A chameleonic macrocyclic peptide with drug delivery applications. Chemical science (2021) 12: 6670-6683 [P, NA]
Payne,C.D., Vadlamani,G., Hajiaghaalipour,F., Muhammad,T., Fisher,M F., Andersson,H.S., Göransson,U., Clark,R.J., Bond,C.S., Mylne,J.S., Rosengren,K.J. Solution NMR and racemic crystallography provide insights into a novel structural class of cyclic plant peptides. RSC chemical biology (2021) 2: 1682-1691 [P, NA]
Pinto,M.E.F., Chan,L.Y., Koehbach,J., Devi,S., Gründemann,C., Gruber,C.W., Gomes,M., Bolzani,V.S., Cilli,E.M., and Craik,D.J. Cyclotides from Brazilian Palicourea sessilis and Their Effects on Human Lymphocytes. J Nat Prod (2021) 84: 81-90 [P, NA]
Rajendran,S., Slazak,B., Mohotti,S., Strömstedt,A.A., Göransson,U. and Gunasekera,S. Tropical vibes from Sri Lanka - cyclotides from Viola betonicifolia by transcriptome and mass spectrometry analysis. Phytochemistry (2021) 187: 112749-0 [P, NA]
Slazak,B., Kaltenböck,K., Steffen,K., Rogala,M., Rodríguez-Rodríguez,P., Nilsson,A., Shariatgorji,R. and Göransson,U. Cyclotide host-defense tailored for species and environments in violets from the Canary Islands. Sci Rep (2021) 11: 12452-0 [P, NA]
2020 Dancewicz,K., Slazak,B., Kie?kiewicz,M., Kapusta,M., Bohdanowicz,J., and Gabry?,B. Behavioral and physiological effects of Viola spp. cyclotides on Myzus persicae (Sulz.) Journal of Insect Physiology (2020) 122: 104025-0 [P, NA]
Dang,T.T., Chan,L.Y., Huang,Y.H., Nguyen,L.T.T., Kaas,Q., Huynh,T. and Craik,D.J. Exploring the Sequence Diversity of Cyclotides from Vietnamese Viola Species. J Nat Prod (2020) 83: 1817-1828 [P, NA]
Du, J., Yap, K., Chan, L.Y., Rehm, F.B., Looi, F.Y., Poth, A.G., Gilding, E.K., Kaas, Q., Durek, T. and Craik, D.J. A bifunctional asparaginyl endopeptidase efficiently catalyzes both cleavage and cyclization of cyclic trypsin inhibitors Nature communications (2020) 11: 1575-0 [P, NA]
Du,Q., Chan,L.Y., Gilding,E.K., Henriques,S.T., Condon,N.D., Ravipati,A.S., Kaas,Q., Huang,Y.H. and Craik,D.J. Discovery and mechanistic studies of cytotoxic cyclotides from the medicinal herb Hybanthus enneaspermus. J Biol Chem (2020) 295: 10911-10925 [P, NA]
Du,Q., Huang,Y.H., Bajpai,A., Frosig-Jorgensen,M., Zhao,G. and Craik,D.J. Evaluation of the in Vivo Aphrodisiac Activity of a Cyclotide Extract from Hybanthus enneaspermus. J Nat Prod (2020) : 0-0 [P, NA]
Fisher, M.F., Zhang, J., Berkowitz, O., Whelan, J. and Mylne, J.S. Cyclic Peptides in Seed of Annona muricata Are Ribosomally Synthesized Journal of Natural Products. (2020) 83: 1167-1173 [P, NA]
Kalmankar,N.V., Venkatesan,R., Balaram,P. and Sowdhamini,R. Transcriptomic profiling of the medicinal plant Clitoria ternatea: identification of potential genes in cyclotide biosynthesis. Sci Rep (2020) 10: 12658-0 [P, NA]
Mishra,M., Singh,V., Tellis,M.B., Joshi,R.S. and Singh,S. Repurposing the McoTI-II Rigid Molecular Scaffold in to Inhibitor of Papain Superfamily Cysteine Proteases. Pharmaceuticals (Basel) (2020) 14: 1-17 [P, NA]
Oguis, G.K., Gilding, E.K., Huang, Y.H., Poth, A.G., Jackson, M.A. and Craik, D.J. Insecticidal diversity of butterfly pea (Clitoria ternatea) accessions Industrial Crops and Products (2020) 147: 112214-0 [P, NA]
Parsley,N.C., Williams,O.L. and Hicks,L.M. Exploring the Diversity of Cysteine-Rich Natural Product Peptides via MS/MS Fingerprint Ions. J Am Soc Mass Spectrom (2020) 31: 1833-1843 [P, NA]
Smithies, B.J., Huang, Y.H., Jackson, M.A., Yap, K., Gilding, E.K., Harris, K.S., Anderson, M.A. and Craik, D.J., Circular permutation of the native enzyme-mediated cyclization position in cyclotides ACS Chemical Biology (2020) 15: 962-969 [P, NA]
Zou, X.G., Li, J., Sun, P.L., Fan, Y.W., Yang, J.Y. and Deng, Z.Y. Orbitides isolated from flaxseed induce apoptosis against SGC-7901 adenocarcinoma cells International Journal of Food Sciences and Nutrition (2020) : 1-11 [P, NA]
2019 Du J, Chan LY, Poth AG, Craik DJ Discovery and Characterization of Cyclic and Acyclic Trypsin Inhibitors from Momordica dioica. J Nat Prod. (2019) 82: 293-300 [P, NA]
Fisher, M.F., Payne, C.D., Rosengren, K.J. and Mylne, J.S. An orbitide from Ratibida columnifera seed containing 16 amino acid residues J Nat Prod (2019) 82: 2152-2158 [P, NA]
Parsley, Nicole C., Patric W. Sadecki, Conrad J. Hartmann, and Leslie M. Hicks Viola "inconspicua" No More: An Analysis of Antibacterial Cyclotides. J Nat Prod (2019) 82: 2537-2543 [P, NA]
Poth, A.G., Huang, Y.H., Le, T.T., Kan, M.W. and Craik, D.J., Pharmacokinetic characterization of kalata B1 and related therapeutics built on the cyclotide scaffold Int J Pharm (2019) 565: 437-446 [P, NA]
Sternberger,A.L., Bowman,M.J., Kruse,C.P.S., Childs,K.L., Ballard, H.E., and Wyatt,S.E. Transcriptomics Identifies Modules of Differentially Expressed Genes and Novel Cyclotides in Viola pubescens. Front Plant Sci (2019) 10: 156-0 [P, NA]
2018 Álvarez, C.A., Santana, P.A., Luna, O., Cárdenas, C., Albericio, F., Romero, M.S., and Guzmán, F. Chemical Synthesis and Functional Analysis of VarvA Cyclotide Molecules (2018) 23: 952-0 [P, NA]
Bobey,A.F., Pinto,M.E.F., Cilli,E.M., Lopes,N.P. and Bolzani,V.D.S. A Cyclotide Isolated from Noisettia orchidiflora (Violaceae). Planta Med. (2018) 84: 947-952 [P, NA]
Fisher, M.F., Zhang, J., Taylor, N.L., Howard, M.J., Berkowitz, O., Debowski, A.W., Behsaz, B., Whelan, J., Pevzner, P.A. and Mylne, J.S. A family of small, cyclic peptides buried in preproalbumin since the Eocene epoch Plant direct (2018) 2: 0-0 [P, NA]
Keov,P., Liutkevi?i?t?,Z., Hellinger,R. and Gruber,C.W. Discovery of peptide probes to modulate oxytocin-type receptors of insects. Sci Rep (2018) 8: 10020-0 [P, NA]
Kwon, S., Duarte, J.N., Li, Z., Ling, J.J., Cheneval, O., Durek, T., Schroeder, C.I., Craik, D.J. and Ploegh, H.L. Targeted delivery of cyclotides via conjugation to a nanobody ACS chemical biology (2018) 13: 2973-2980 [P, NA]
Niyomploy, P., Chan, L.Y., Harvey, P.J., Poth, A.G., Colgrave, M.L. and Craik, D.J Discovery and characterization of cyclotides from Rinorea species Journal of natural products (2018) 81: 2512-2520 [P, NA]
Parsley, N.C., Kirkpatrick, C.L., Crittenden, C.M., Rad, J.G., Hoskin, D.W., Brodbelt, J.S. and Hicks, L.M. PepSAVI-MS reveals anticancer and antifungal cycloviolacins in Viola odorata Phytochemistry (2018) 152: 61-70 [P, NA]
Pinto,M.E.F., Najas,J.Z.G., Magalhães,L.G., Bobey,A.F., Mendonça,J.N., Lopes,N.P., Leme,F.M., Teixeira,S.P., Trovó,M., Andricopulo,A.D., Koehbach,J., Gruber,C.W., Cilli,E.M. and Bolzani,V.S. Inhibition of Breast Cancer Cell Migration by Cyclotides Isolated from Pombalia calceolaria. J. Nat. Prod. (2018) 81: 1203-1208 [P, NA]
Ramalho, S.D., Pinto, M.E.F., Ferreira, D. and Bolzani, V.S. Biologically active orbitides from the Euphorbiaceae family Planta medica (2018) 84: 558-567 [P, NA]
Slazak,B., Kapusta,M., Strömstedt,A.A., S?omka,A., Krychowiak,M., Shariatgorji,M., Andrén,P.E., Bohdanowicz,J., Kuta,E., and Göransson,U. How Does the Sweet Violet (Viola odorata L.) Fight Pathogens and Pests - Cyclotides as a Comprehensive Plant Host Defense System Frontiers in plant science (2018) 9: 0-0 [P, NA]
Zou, X.G., Hu, J.N., Li, J., Yang, J.Y., Du, Y.X., Yu, Y.F. and Deng, Z.Y iCellular uptake of [1–9-NαC]-linusorb B2 and [1–9-NαC]-linusorb B3 isolated from flaxseed, and their antitumor activities in human gastric SGC-7901 cells Journal of Functional Foods (2018) 48: 692-703 [P, NA]
2017 Fahradpour, M., Keov, P., Tognola, C., Perez-Santamarina, E., McCormick, P.J., Ghassempour, A. and Gruber, C.W. Cyclotides Isolated from an Ipecac Root Extract Antagonize the Corticotropin Releasing Factor Type 1 Receptor Frontiers in pharmacology (2017) 8: 616-0 [P, NA]
Hellinger, R., Thell, K., Vasileva, M., Muhammad, T., Gunasekera, S., Kümmel, D., Göransson, U., Becker, C.W. and Gruber, C.W Chemical proteomics for target discovery of head-to-tail cyclized mini-proteins Frontiers in chemistry (2017) 5: 73-0 [P, NA]
Jayasena, A.S., Fisher, M.F., Panero, J.L., Secco, D., Bernath-Levin, K., Berkowitz, O., Taylor, N.L., Schilling, E.E., Whelan, J. and Mylne, J.S Stepwise evolution of a buried inhibitor peptide over 45 My Molecular biology and evolution (2017) 34: 1505-1516 [P, NA]
Kirkpatrick, C.L., Broberg, C.A., McCool, E.N., Lee, W.J., Chao, A., McConnell, E.W., Pritchard, D.A., Hebert, M., Fleeman, R., Adams, J. and Jamil, A. The "PepSAVI-MS" Pipeline for Natural Product Bioactive Peptide Discovery Analytical chemistry (2017) 89: 1194-1201 [P, NA]
Lesniak, W.G., Aboye, T., Chatterjee, S., Camarero, J.A. and Nimmagadda, S. In vivo evaluation of an engineered cyclotide as specific CXCR4 imaging reagent Chemistry–A European Journal (2017) 23: 14469-14475 [P, NA]
Narayani, M., Chadha, A. and Srivastava, S Cyclotides from the indian medicinal plant Viola odorata (Banafsha): Identification and characterization Journal of natural products (2017) 80: 1972-1980 [P, NA]
Nworu, C.S., Ejikeme, T.I., Ezike, A.C., Ndu, O., Akunne, T.C., Onyeto, C.A., Okpalanduka, P. and Akah, P.A. Anti-plasmodial and anti-inflammatory activities of cyclotide-rich extract and fraction of Oldenlandia affinis (R. & S.) DC (Rubiaceae) African health sciences (2017) 17: 827-843 [P, NA]
Ravipati AS, Poth AG, Troeira Henriques S, Bhandari M, Huang YH, Nino J, Colgrave ML, Craik DJ. Understanding the Diversity and Distribution of Cyclotides from Plants of Varied Genetic Origin. J Nat Prod. (2017) 80: 1522-1530 [P, NA]
2016 Wang, D., Chen, J., Zhu, J. and Mou, Y. Novel cyclotides from Hedyotis biflora has potent bactericidal activity against Gram-negative bacteria and E. coli drug resistance Int. J. Clin. Exp. Med (2016) 9: 9521-9526 [P, NA]
Abdul Ghani H, Henriques ST, Huang YH, Swedberg JE, Schroeder CI, Craik DJ Structural and functional characterisation of chimeric cyclotides from the Möbius and trypsin inhibitor subfamilies Biopolymers (2016) : 0-0 [P, NA]
Aboye, T., Meeks, C.J., Majumder, S., Shekhtman, A., Rodgers, K. and Camarero, J.A Design of a MCoTI-based cyclotide with angiotensin (1-7)-like activity Molecules (2016) 21: 152-0 [P, NA]
Attah,A.F., Hellinger,R., Sonibare,M.A., Moody,J.O., Arrowsmith,S., Wray,S. and Gruber,C.W. Ethnobotanical survey of Rinorea dentata (Violaceae) used in South-Western Nigerian ethnomedicine and detection of cyclotides. J Ethnopharmacol (2016) 179: 83-91 [P, NA]
Burnett, P.G.G., Olivia, C.M., Okinyo-Owiti, D.P. and Reaney, M.J.T. Orbitide composition of the flax Core collection (FCC) Journal of agricultural and food chemistry (2016) 64: 5197-5206 [P, NA]
Cunha, N.B.D., Barbosa, A.E.A.D.D., de Almeida, R.G., Porto, W.F., Maximiano, M.R., Álvares, L.C.S., Munhoz, C.B.R., Eugênio, C.U.O., Viana, A.A.B., Franco, O.L. and Dias, S.C Cloning and characterization of novel cyclotides genes from South American plants Peptide Science (2016) 106: 784-795 [P, NA]
Dos S Beirigo,P.J., Torquato,H.F., Dos Santos,C.H., Carvalho,M.G., Castro,R.N., Paredes-Gamero,E.J., de Sousa,P.T. Jr. and da Silva,V.C. [1-8-N?C]-Zanriorb A1, a Proapoptotic Orbitide from Leaves of Zanthoxylum riedelianum. J Nat Prod (2016) 79: 1454-1458 [P, NA]
Esmaeili, M. A., Abagheri-Mahabadi, N., Hashempour, H., Farhadpour, M., Gruber, C. W., & Ghassempour, A. Viola plant cyclotide vigno 5 induces mitochondria-mediated apoptosis via cytochrome C release and caspases activation in cervical cancer cells Fitoterapia (2016) 109: 162-168 [P, NA]
Esmaeili,M.A., Abagheri-Mahabadi,N., Hashempour,H., Farhadpour,M., Gruber,C.W. and Ghassempour,A. Viola plant cyclotide vigno 5 induces mitochondria-mediated apoptosis via cytochrome C release and caspases activation in cervical cancer cells. Fitoterapia (2016) 109: 162-168 [P, NA]
Farhadpour,M., Hashempour,H., Talebpour,Z., A-Bagheri,N., Shushtarian,M.S., Gruber,C.W. and Ghassempour,A. Microwave-assisted extraction of cyclotides from Viola ignobilis. Anal. Biochem. (2016) 497: 83-89 [P, NA]
Gilding,E.K., Jackson,M.A., Poth,A.G., Henriques,S.T., Prentis,P.J., Mahatmanto,T. and Craik,D.J. Gene coevolution and regulation lock cyclic plant defence peptides to their targets. New Phytol. (2016) 210: 717-730 [P, NA]
Glantz,S.T., Carpenter,E.J., Melkonian,M., Gardner,K.H., Boyden,E.S., Wong,G.K. and Chow,B.Y. Functional and topological diversity of LOV domain photoreceptors. Proc. Natl. Acad. Sci. U.S.A. (2016) 113: 0-51 [P, NA]
Matsuura HN, Poth AG, Yendo AC, Fett-Neto AG, Craik DJ. Isolation and Characterization of Cyclotides from Brazilian Psychotria: Significance in Plant Defense and Co-occurrence with Antioxidant Alkaloids. J Nat Prod. (2016) 79: 3006-3013 [P, NA]
Nguyen KN, Nguyen GK, Nguyen PQ, Ang KH, Dedon PC, Tam JP Immunostimulating and Gram-negative-specific Antibacterial Cyclotides from the Butterfly Pea Clitoria ternatea. FEBS J (2016) doi:10.1111/febs.13720: 0-0 [P, NA]
Niyomploy, P., Chan, L.Y., Poth, A.G., Colgrave, M.L., Sangvanich, P. and Craik, D.J. Discovery, isolation, and structural characterization of cyclotides from Viola sumatrana Miq Peptide Science (2016) 106: 796-805 [P, NA]
Pinto, M.F., Silva, O.N., Viana, J.C., Porto, W.F., Migliolo, L., B. da Cunha, N., Gomes Jr, N., Fensterseifer, I.C., Colgrave, M.L., Craik, D.J. and Dias, S.C Characterization of a Bioactive Acyclotide from Palicourea rigida Journal of natural products (2016) 79: 2767-2773 [P, NA]
Serra,A., Hemu,X., Nguyen,G.K., Nguyen,N.T., Sze,S.K. and Tam,J.P. A high-throughput peptidomic strategy to decipher the molecular diversity of cyclic cysteine-rich peptides. Sci Rep (2016) 6: 23005-0 [P, NA]
Strömstedt,A.A., Kristiansen,P.E., Gunasekera,S., Grob,N., Skjeldal,L. and Göransson,U. Selective membrane disruption by the cyclotide kalata B7: complex ions and essential functional groups in the phosphatidylethanolamine binding pocket. Biochim Biophys Acta (2016) 1858: 1317-1327 [P, NA]
Thell K, Hellinger R, Sahin E, Michenthaler P, Gold-Binder M, Haider T, Kuttke M, Liutkevičiūtė Z, Göransson U, Gründemann C, Schabbauer G, Gruber CW Oral activity of a nature-derived cyclic peptide for the treatment of multiple sclerosis Proc Natl Acad Sci USA (2016) 113: 3960-3965 [P, NA]
Wang, D., Chen, J., Zhu, J. and Mou, Y. Novel cyclotides from Hedyotis biflora has potent bactericidal activity against Gram-negative bacteria and E. coli drug resistance Int. J. Clin. Exp. Med (2016) 9: 9521-9526 [P, NA]
2015 Burman, R., Yeshak, M.Y., Larsson, S., Craik, D.J., Rosengren, K.J. and Göransson, U. Distribution of circular proteins in plants: large-scale mapping of cyclotides in the Violaceae Frontiers in plant science (2015) 6: 855-0 [P, NA]
Burnett, P.G.G., Jadhav, P.D., Okinyo-Owiti, D.P., Poth, A.G. and Reaney, M.J. Glycine-containing flaxseed orbitides Journal of natural products (2015) 78: 681-688 [P, NA]
Cândido-Bacani, P.D.M., Figueiredo, P.D.O., Matos, M.D.F., Garcez, F.R. and Garcez, W.S. Cytotoxic orbitide from the latex of Croton urucurana Journal of natural products (2015) 78: 2754-2760 [P, NA]
Hellinger,R., Koehbach,J., Puigpinós,A., Clark,R.J., Tarragó,T., Giralt,E. and Gruber,C.W. Inhibition of Human Prolyl Oligopeptidase Activity by the Cyclotide Psysol 2 Isolated from Psychotria solitudinum. J. Nat. Prod. (2015) 78: 1073-1082 [P, NA]
Hellinger,R., Koehbach,J., Soltis,D.E., Carpenter,E.J., Wong,G.K. and Gruber,C.W. Peptidomics of Circular Cysteine-Rich Plant Peptides: Analysis of the Diversity of Cyclotides from Viola tricolor by Transcriptome and Proteome Mining. J. Proteome Res. (2015) 14: 4851-4862 [P, NA]
Hu E, Wang D, Chen J, Tao X. Novel cyclotides from Hedyotis diffusa induce apoptosis and inhibit proliferation and migration of prostate cancer cells Int J Clin Exp Med (2015) 8: 4059-4065 [P, NA]
Huang,Y.H., Henriques,S.T., Wang,C.K., Thorstholm,L., Daly,N.L., Kaas,Q. and Craik,D.J. Design of substrate-based BCR-ABL kinase inhibitors using the cyclotide scaffold. Sci Rep (2015) 5: 12974-0 [P, NA]
Mahatmanto, T., Mylne, J.S., Poth, A.G., Swedberg, J.E., Kaas, Q., Schaefer, H. and Craik, D.J. The evolution of Momordica cyclic peptides. Molecular biology and evolution 32 (2015) 2: 392-405 [P, NA]
Pinto,M.E., Batista,J.M. Jr., Koehbach,J., Gaur,P., Sharma,A., Nakabashi,M., Cilli,E.M., Giesel,G.M., Verli,H., Gruber,C.W., Blanch,E.W., Tavares,J.F., da Silva,M.S., Garcia,C.R. and Bolzani,V.S. Ribifolin, an orbitide from Jatropha ribifolia, and its potential antimalarial activity. J. Nat. Prod. (2015) 78: 374-380 [P, NA]
Ravipati,A.S., Henriques,S.T., Poth,A.G., Kaas,Q., Wang,C.K., Colgrave,M.L. and Craik,D.J. Lysine-rich Cyclotides: A New Subclass of Circular Knotted Proteins from Violaceae. ACS Chem. Biol. (2015) 10: 2491-2500 [P, NA]
Slazak, B., Jacobsson, E., Kuta, E. and Göransson, U. Exogenous plant hormones and cyclotide expression in Viola uliginosa (Violaceae Phytochemistry (2015) 117: 527-536 [P, NA]
Zhang, J., Li, J., Huang, Z., Yang, B., Zhang, X., Li, D., Craik, D.J., Baker, A.J., Shu, W. and Liao, B. Transcriptomic screening for cyclotides and other cysteine-rich proteins in the metallophyte Viola baoshanensis. Journal of plant physiology (2015) 178: 17-26 [P, NA]
2014 Altei,W.F., Picchi,D.G., Abissi,B.M., Giesel,G.M., Flausino,O. Jr., Reboud-Ravaux,M., Verli,H., Crusca,E. Jr., Silveira,E.R., Cilli,E.M. and Bolzani,V.S. Jatrophidin I, a cyclic peptide from Brazilian Jatropha curcas L.: isolation, characterization, conformational studies and biological activity. Phytochemistry (2014) 107: 91-96 [P, NA]
Ding, X., Bai, D. and Qian, J Novel cyclotides from Hedyotis biflora inhibit proliferation and migration of pancreatic cancer cell in vitro and in vivo Medicinal Chemistry Research (2014) 23: 1406-1413 [P, NA]
Elliott,A.G., Delay,C., Liu,H., Phua,Z., Rosengren,K.J., Benfield,A.H., Panero,J.L., Colgrave,M.L., Jayasena,A.S., Dunse,K.M., Anderson,M.A., Schilling,E.E., Ortiz-Barrientos,D. and Mylne,J.S. Evolutionary origins of a bioactive peptide buried within Preproalbumin. Plant Cell (2014) 26: 981-995 [P, NA]
Henriques,S.T., Huang,Y.H., Chaousis,S., Wang,C.K. and Craik,D.J. Anticancer and toxic properties of cyclotides are dependent on phosphatidylethanolamine phospholipid targeting. Chembiochem (2014) 15: 1956-1965 [P, NA]
Jia,X., Kwon,S., Wang,C.I., Huang,Y.H., Chan,L.Y., Tan,C.C., Rosengren,K.J., Mulvenna,J.P., Schroeder,C.I. and Craik,D.J. Semienzymatic cyclization of disulfide-rich peptides using Sortase A. J Biol Chem (2014) 289: 6627-6638 [P, NA]
Mu,F., Masuda,Y., Zendo,T., Ono,H., Kitagawa,H., Ito,H., Nakayama,J. and Sonomoto,K. Biological function of a DUF95 superfamily protein involved in the biosynthesis of a circular bacteriocin, leucocyclicin Q. J. Biosci. Bioeng. (2014) 117: 158-164 [P, NA]
Okinyo-Owiti, D.P., Young, L., Burnett, P.G.G. and Reaney, M.J. New flaxseed orbitides: Detection, sequencing, and 15N incorporation Peptide Science (2014) 102: 168-175 [P, NA]
Wang,C.K., King,G.J., Northfield,S.E., Ojeda,P.G. and Craik,D.J. Racemic and quasi-racemic X-ray structures of cyclic disulfide-rich peptide drug scaffolds. Angew Chem Int Ed Engl (2014) 53: 11236-11241 [P, NA]
2013 Hashempour,H., Koehbach,J., Daly,N.L., Ghassempour,A. and Gruber,C.W. Characterizing circular peptides in mixtures: sequence fragment assembly of cyclotides from a violet plant by MALDI-TOF/TOF mass spectrometry. Amino Acids (2013) 44: 581-595 [P, NA]
Ji,Y., Majumder,S., Millard,M., Borra,R., Bi,T., Elnagar,A.Y., Neamati,N., Shekhtman,A. and Camarero,J.A. In vivo activation of the p53 tumor suppressor pathway by an engineered cyclotide. J. Am. Chem. Soc. (2013) 135: 11623-11633 [P, NA]
Koehbach,J., Attah,A.F., Berger,A., Hellinger,R., Kutchan,T.M., Carpenter,E.J., Rolf,M., Sonibare,M.A., Moody,J.O., Wong,G.K., Dessein,S., Greger,H. and Gruber,C.W. Cyclotide discovery in Gentianales revisited-identification and characterization of cyclic cystine-knot peptides and their phylogenetic distribution in Rubiaceae plants. Biopolymers (2013) 100: 438-452 [P, NA]
Koehbach,J., O Brien,M., Muttenthaler,M., Miazzo,M., Akcan,M., Elliott,A.G., Daly,N.L., Harvey,P.J., Arrowsmith,S., Gunasekera,S., Smith,T.J., Wray,S., Goransson,U., Dawson,P.E., Craik,D.J., Freissmuth,M. and Gruber,C.W. Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design. Proc. Natl. Acad. Sci. U.S.A (2013) 110: 21183-21188 [P, NA]
Nguyen,G.K., Lian,Y., Pang,E.W., Nguyen,P.Q., Tran,T.D. and Tam,J.P. Discovery of linear cyclotides in monocot plant Panicum laxum of Poaceae family provides new insights into evolution and distribution of cyclotides in plants. J. Biol. Chem. (2013) 288: 3370-3380 [P, NA]
Zarrabi,M., Dalirfardouei,R., Sepehrizade,Z. and Kermanshahi,R.K. Comparison of the antimicrobial effects of semipurified cyclotides from Iranian Viola odorata against some of plant and human pathogenic bacteria. J. Appl. Microbiol. (2013) 115: 367-375 [P, NA]
2012 Aboye,T.L., Ha,H., Majumder,S., Christ,F., Debyser,Z., Shekhtman,A., Neamati,N. and Camarero,J.A. Design of a novel cyclotide-based CXCR4 antagonist with anti-human immunodeficiency virus (HIV)-1 activity. J. Med. Chem. (2012) 55: 10729-10734 [P, NA]
Eliasen,R., Daly,N.L., Wulff,B.S., Andresen,T.L., Conde-Frieboes,K.W. and Craik,D.J. Design, synthesis, structural and functional characterization of novel melanocortin agonists based on the cyclotide kalata B1. J. Biol. Chem. (2012) 287: 40493-40501 [P, NA]
Mylne,J.S., Chan,L.Y., Chanson,A.H., Daly,N.L., Schaefer,H., Bailey,T.L., Nguyencong,P., Cascales,L. and Craik,D.J. Cyclic peptides arising by evolutionary parallelism via asparaginyl-endopeptidase-mediated biosynthesis. Plant Cell (2012) 24: 2765-2778 [P, NA]
Nguyen,G.K., Lim,W.H., Nguyen,P.Q. and Tam,J.P. Novel cyclotides and uncyclotides with highly shortened precursors from Chassalia chartacea and effects of methionine oxidation on bioactivities. J. Biol. Chem. (2012) 287: 17598-17607 [P, NA]
Pinto,M.F.S., Fensterseifer,I.C.M., Migliolo,L., Sousa,D.A., de Capdville,G., Arboleda-Valencia,J.W., Colgrave,M.L., Craik,D.J., Magalhães,B.S. and Franco,O.L. Identification and structural characterization of novel cyclotide with activity against an insect pest of sugar cane. J Biol Chem (2012) 287: 134-147 [P, NA]
Poth,A.G., Mylne,J.S., Grassl,J., Lyons,R.E., Millar,A.H., Colgrave,M.L. and Craik,D.J. Cyclotides associate with leaf vasculature and are the products of a novel precursor in petunia (Solanaceae). J. Biol. Chem. (2012) 287: 27033-27046 [P, NA]
Tischler,M., Nasu,D., Empting,M., Schmelz,S., Heinz,D.W., Rottmann,P., Kolmar,H., Buntkowsky,G., Tietze,D. and Avrutina,O. Braces for the peptide backbone: insights into structure-activity relationships of protease inhibitor mimics with locked amide conformations. Angew. Chem. Int. Ed. Engl. (2012) 51: 3708-3712 [P, NA]
Wong,C.T., Rowlands,D.K., Wong,C.H., Lo,T.W., Nguyen,G.K., Li,H.Y. and Tam,J.P. Orally active peptidic bradykinin B1 receptor antagonists engineered from a cyclotide scaffold for inflammatory pain treatment. Angew. Chem. Int. Ed. Engl. (2012) 51: 5620-5624 [P, NA]
2011 Borrero J, Brede DA, Skaugen M, Diep DB, Herranz C, Nes IF, Cintas LM, Hernández PE Characterization of garvicin ML, a novel circular bacteriocin produced by Lactococcus garvieae DCC43, isolated from mallard ducks (Anas platyrhynchos). Appl Environ Microbiol (2011) 77: 369-373 [P, NA]
Burman,R., Strömstedt,A.A., Malmsten,M. and Göransson,U. Cyclotide-membrane interactions: defining factors of membrane binding, depletion and disruption. Biochim. Biophys. Acta (2011) 1808: 2665-2673 [P, NA]
Cascales,L., Henriques,S.T., Kerr,M.C., Huang,Y.H., Sweet,M.J., Daly,N.L. and Craik,D.J. Identification and characterization of a new family of cell-penetrating peptides: cyclic cell-penetrating peptides. J. Biol. Chem. (2011) 286: 36932-36943 [P, NA]
Chan,L.Y., Gunasekera,S., Henriques,S.T., Worth,N.F., Le,S.J., Clark,R.J., Campbell,J.H., Craik,D.J. and Daly,N.L. Engineering pro-angiogenic peptides using stable, disulfide-rich cyclic scaffolds. Blood (2011) 118: 6709-6717 [P, NA]
Condie JA, Nowak G, Reed DW, Balsevich JJ, Reaney MJ, Arnison PG, Covello PS The biosynthesis of Caryophyllaceae-like cyclic peptides in Saponaria vaccaria L. from DNA-encoded precursors. Plant J (2011) 67: 682-90 [P, NA]
Contreras,J., Elnagar,A.Y., Hamm-Alvarez,S.F. and Camarero,J.A. Cellular uptake of cyclotide MCoTI-I follows multiple endocytic pathways. J Control Release (2011) 155: 134-143 [P, NA]
Hashempour,H., Ghassempour,A., Daly,N.L., Spengler,B. and Römpp,A. Analysis of cyclotides in Viola ignobilis by Nano liquid chromatography fourier transform mass spectrometry. Protein Pept. Lett. (2011) 18: 747-752 [P, NA]
He,W., Chan,L.Y., Zeng,G., Daly,N.L., Craik,D.J. and Tan,N. Isolation and characterization of cytotoxic cyclotides from Viola philippica. Peptides (2011) 32: 1719-1723 [P, NA]
Masuda,Y., Ono,H., Kitagawa,H., Ito,H., Mu,F., Sawa,N., Zendo,T. and Sonomoto,K. Identification and characterization of leucocyclicin Q, a novel cyclic bacteriocin produced by Leuconostoc mesenteroides TK41401. Appl. Environ. Microbiol. (2011) 77: 8164-8170 [P, NA]
Mylne JS, Colgrave ML, Daly NL, Chanson AH, Elliott AG, McCallum EJ, Jones A, Craik DJ. Albumins and their processing machinery are hijacked for cyclic peptides in sunflower. Nat Chem Biol (2011) 7: 257-259 [P, NA]
Nguyen,G.K., Zhang,S., Nguyen,N.T., Nguyen,P.Q., Chiu,M.S., Hardjojo,A. and Tam,J.P. Discovery and characterization of novel cyclotides originated from chimeric precursors consisting of albumin-1 chain a and cyclotide domains in the Fabaceae family. J. Biol. Chem. (2011) 286: 24275-24287 [P, NA]
Nguyen,G.K., Zhang,S., Wang,W., Wong,C.T., Nguyen,N.T. and Tam,J.P. Discovery of a linear cyclotide from the bracelet subfamily and its disulfide mapping by top-down mass spectrometry. J. Biol. Chem. (2011) 286: 44833-44844 [P, NA]
Ovesen,R.G., Nielsen,J. and Hansen,H.C. Biomedicine in the environment: sorption of the cyclotide kalata B2 to montmorillonite, goethite, and humic acid. Environ. Toxicol. Chem. (2011) 30: 1785-1792 [P, NA]
Poth AG, Colgrave ML, Lyons RE, Daly NL, Craik DJ Discovery of an unusual biosynthetic origin for circular proteins in legumes Proc Natl Acad Sci USA (2011) 108: 10127-10132 [P, NA]
Poth AG, Colgrave ML, Philip R, Kerenga B, Daly NL, Anderson MA, Craik DJ Discovery of cyclotides in the fabaceae plant family provides new insights into the cyclization, evolution, and distribution of circular proteins. ACS Chem Biol (2011) 6: 345-355 [P, NA]
Sando,L., Henriques,S.T., Foley,F., Simonsen,S.M., Daly,N.L., Hall,K.N., Gustafson,K.R., Aguilar,M.I. and Craik,D.J. A Synthetic mirror image of kalata B1 reveals that cyclotide activity is independent of a protein receptor. Chembiochem (2011) 12: 2456-2462 [P, NA]
Wang,C.K., Clark,R.J., Harvey,P.J., Rosengren,K.J., Cemazar,M. and Craik,D.J. The role of conserved Glu residue on cyclotide stability and activity: a structural and functional study of kalata B12, a naturally occurring Glu to Asp mutant. Biochemistry (2011) 50: 4077-4086 [P, NA]
Wong CT, Taichi M, Nishio H, Nishiuchi Y, Tam JP Optimal Oxidative Folding of the Novel Antimicrobial Cyclotide from Hedyotis biflora Requires High Alcohol Concentrations. Biochemistry (2011) [ahead]: 0-0 [P, NA]
Yeshak MY, Burman R, Asres K, Göransson U Cyclotides from an Extreme Habitat: Characterization of Cyclic Peptides from Viola abyssinica of the Ethiopian Highlands J Nat Prod (2011) [ahead]: 0-0 [P, NA]
Yuan,C., Chen,L., Meehan,E.J., Daly,N., Craik,D.J., Huang,M. and Ngo,J.C. Structure of catalytic domain of Matriptase in complex with Sunflower trypsin inhibitor-1. BMC Struct. Biol. (2011) 11: 30-0 [P, NA]
Zenoni,S., D Agostino,N., Tornielli,G.B., Quattrocchio,F., Chiusano,M.L., Koes,R., Zethof,J., Guzzo,F., Delledonne,M., Frusciante,L., Gerats,T. and Pezzotti,M. Revealing impaired pathways in the an11 mutant by high-throughput characterization of Petunia axillaris and Petunia inflata transcriptomes. Plant J. (2011) 68: 11-27 [P, NA]
2010 Breuillin,F., Schramm,J., Hajirezaei,M., Ahkami,A., Favre,P., Druege,U., Hause,B., Bucher,M., Kretzschmar,T., Bossolini,E., Kuhlemeier,C., Martinoia,E., Franken,P., Scholz,U. and Reinhardt,D. Phosphate systemically inhibits development of arbuscular mycorrhiza in Petunia hybrida and represses genes involved in mycorrhizal functioning. Plant J. (2010) 64: 1002-1017 [P, NA]
Burman R, Gruber CW, Rizzardi K, Herrmann A, Craik DJ, Gupta MP, Göransson U Cyclotide proteins and precursors from the genus Gloeospermum: filling a blank spot in the cyclotide map of Violaceae. Phytochemistry (2010) 71: 13-20 [P, NA]
Burman, R., Svedlund, E., Felth, J., Hassan, S., Herrmann, A., Clark, R.J., Craik, D.J., Bohlin, L., Claeson, P., Göransson, U. and Gullbo, J Evaluation of toxicity and antitumor activity of cycloviolacin O2 in mice Peptide Science (2010) 94: 626-634 [P, NA]
Colgrave ML, Poth AG, Kaas Q, Craik DJ A new ‘era’ for cyclotide sequencing. Biopolymers: Peptide Science (2010) 94: 592-601 [P, NA]
Daly NL, Chen B, Nguyencong P, Craik DJ Structure and Activity of the Leaf-Specific Cyclotide vhl-2. Australian Journal of Chemistry (2010) 63: 771-778 [P, NA]
Gerlach SL, Burman R, Bohlin L, Mondal D, Göransson U Isolation, characterization, and bioactivity of cyclotides from the Micronesian plant Psychotria leptothyrsa J Nat Prod (2010) 73: 1207-1213 [P, NA]
Gerlach SL, Rathinakumar R, Chakravarty G, Göransson U, Wimley WC, Darwin SP, Mondal D Anticancer and chemosensitizing abilities of cycloviolacin 02 from Viola odorata and psyle cyclotides from Psychotria leptothyrsa. Biopolymers (2010) 94: 617-625 [P, NA]
Mehmood, R. and Malik, A. Isolation and characterization of crotosparsamide, a new cyclic nonapeptide from Croton sparsiflorus Natural product communications (2010) 5: 1885-1888 [P, NA]
Mylne JS, Wang CK, van der Weerden NL, Craik DJ Cyclotides are a component of the innate defense of Oldenlandia affinis. Biopolymers (2010) 94: 635-646 [P, NA]
Plan MR, Rosengren KJ, Sando L, Daly NL, Craik DJ Structural and biochemical characteristics of the cyclotide Kalata B5 from Oldenlandia affinis. Biopolymers (2010) 94: 647-658 [P, NA]
Puttamadappa,S.S., Jagadish,K., Shekhtman,A. and Camarero,J.A. Backbone dynamics of cyclotide MCoTI-I free and complexed with trypsin. Angew. Chem. Int. Ed. Engl. (2010) 49: 7030-7034 [P, NA]
Qin Q, McCallum EJ, Kaas Q, Suda J, Saska I, Craik DJ, Mylne JS. Identification of candidates for cyclotide biosynthesis and cyclisation by expressed sequence tag analysis of Oldenlandia affinis. BMC Genomics (2010) 11: 111-0 [P, NA]
Stegemann C, Tsvetkova EV, Aleshina GM, Lehrer RI, Kokryakov VN, Hoffmann R. De novo sequencing of two new cyclic theta-defensins from baboon (Papio hamadryas) leukocytes by matrix-assisted laser desorption/ionization mass spectrometry. Rapid Commun Mass Spectrom (2010) 24: 599-604 [P, NA]
Tang J, Wang CK, Pan X, Yan H, Zeng G, Xu W, He W, Daly NL, Craik DJ, Tan N Isolation and characterization of cytotoxic cyclotides from Viola tricolor. Peptides (2010) 31: 1434-1440 [P, NA]
Tang J, Wang CK, Pan X, Yan He, Zeng G, Xu W, He W, Daly NL, Craik DJ, Tan N Isolation and Characterization of Bioactive Cyclotides from Viola labridorica Helvetica Chimica Acta (2010) 93: 2287-2295 [P, NA]
Xiang B, Du GH, Wang XC, Zhang SX, Qin XY, Kong JQ, Cheng KD, Li YJ, Wang W Elucidating the structure of two cyclotides of Viola tianshanica maxim by MALDI TOF/TOF MS analysis Yao Xue Xue Bao (2010) 45: 1402-1409 [P, NA]
2009 Göransson,U., Herrmann,A., Burman,R., Haugaard-Jönsson,L.M. and Rosengren,K.J. The conserved glu in the cyclotide cycloviolacin O2 has a key structural role. Chembiochem (2009) 10: 2354-2360 [P, NA]
Martin-Visscher,L.A., Gong,X., Duszyk,M. and Vederas,J.C. The three-dimensional structure of carnocyclin A reveals that many circular bacteriocins share a common structural motif. J. Biol. Chem. (2009) 284: 28674-28681 [P, NA]
Sawa N, Zendo T, Kiyofuji J, Fujita K, Himeno K, Nakayama J, Sonomoto K Identification and characterization of lactocyclicin Q, a novel cyclic bacteriocin produced by Lactococcus sp. strain QU 12. Appl Environ Microbiol (2009) 75: 1552-1558 [P, NA]
Trabi M, Mylne JS, Bharathi R, Sando L and Craik DJ Circular proteins from Melicytus (Violaceae) refine the conserved protein and gene architecture of cyclotides. Org Biomol Chem (2009) 7: 2378-2388 [P, NA]
Wang CK, Colgrave ML, Ireland DC, Kaas Q, Craik DJ Despite a conserved cystine knot motif, different cyclotides have different membrane binding modes. Biophys J. (2009) 97: 1471-1481 [P, NA]
Wang CK, Hu SH, Martin JL, Sjögren T, Hajdu J, Bohlin L, Claeson P, Göransson U, Rosengren KJ, Tang J, Tan NH, Craik DJ Combined X-ray and NMR analysis of the stability of the cyclotide cystine knot fold that underpins its insecticidal activity and potential use as a drug scaffold. J Biol Chem (2009) 284: 10672-10683 [P, NA]
Zhang J, Liao B, Craik DJ, Li J-T, Hu M, Shu W Identification of two suites of cyclotide precursor genes from metallophyte Viola baoshanensis: cDNA sequence variation, alternative RNA splicing and potential cyclotide diversity Gene (2009) 431: 23-32 [P, NA]
2008 Barbeta BL, Marshall AT, Gillon AD, Craik DJ, Anderson MA Plant cyclotides disrupt epithelial cells in the midgut of lepidopteran larvae Proc Natl Acad Sci U S A (2008) 105: 1221-1225 [P, NA]
Brueckner F, Cramer P Structural Basis of Transcription Inhibition by Alpha-Amanitin and Implications for RNA Polymerase II Translocation. Nat Struct Mol Biol (2008) 15: 811-818 [P, NA]
Cemazar M, Joshi A, Daly NL, Mark AE, Craik DJ The structure of a two-disulfide intermediate assists in elucidating the oxidative folding pathway of a cyclic cystine knot protein. Structure (2008) 16: 842-851 [P, NA]
Colgrave ML, Kotze AC, Huang YH, O'Grady J, Simonsen SM, Craik DJ. Cyclotides: natural, circular plant peptides that possess significant activity against gastrointestinal nematode parasites of sheep. Biochemistry (2008) 47: 5581-5589 [P, NA]
Colgrave ML, Kotze AC, Ireland DC, Wang CK, Craik DJ The anthelmintic activity of the cyclotides: natural variants with enhanced activity Chembiochem (2008) 9: 1939-1945 [P, NA]
Garcia AE, Osapay G, Tran PA, Yuan J, Selsted ME Isolation, synthesis, and antimicrobial activities of naturally occurring theta-defensin isoforms from baboon leukocytes. Infect Immun (2008) 76: 5853-5891 [P, NA]
Gruber CW, Elliott AG, Ireland DC, Delprete PG, Dessein S, Göransson U, Trabi M, Wang CK, Kinghorn AB, Robbrecht E, Craik DJ Distribution and evolution of circular miniproteins in flowering plants. Plant Cell (2008) 20: 2471-2483 [P, NA]
Herrmann A, Burman R, Mylne JS, Karlsson G, Gullbo J, Craik DJ, Clark RJ, Goransson U The alpine violet, Viola biflora, is a rich source of cyclotides with potent cytotoxicity Phytochemistry (2008) 69: 939-952 [P, NA]
Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ Cyclotides as natural anti-HIV agents Biopolymers (2008) 90: 51-60 [P, NA]
Martin-Visscher,L.A., van Belkum,M.J., Garneau-Tsodikova,S., Whittal,R.M., Zheng,J., McMullen,L.M. and Vederas,J.C. Isolation and characterization of carnocyclin a, a novel circular bacteriocin produced by Carnobacterium maltaromaticum UAL307. Appl. Environ. Microbiol. (2008) 74: 4756-4763 [P, NA]
Mozoruk J, Hunnicutt LE, Hunter WB, Bausher MG CsV03-3 is a member of a novel gene family from citrus that encodes a protein with DNA binding activity and whose expression is responsive to defense signals and abiotic stress. J Plant Physiol (2008) 165: 531-543 [P, NA]
Plan MR, Saska I, Cagauan AG, Craik DJ Backbone cyclised peptides from plants show molluscicidal activity against the rice pest Pomacea canaliculata (golden apple snail) J Agric Food Chem (2008) 56: 5237-5241 [P, NA]
Shenkarev ZO, Nadezhdin KD, Lyukmanova EN, Sobol VA, Skjeldal L, Arseniev AS Divalent cation coordination and mode of membrane interaction in cyclotides: NMR spatial structure of ternary complex Kalata B7/Mn2+/DPC micelle. J Inorg Biochem (2008) 102: 1246-1256 [P, NA]
Shenkarev ZO, Nadezhdin KD, Sobol VA, Sobol AG, Skjeldal L, Arseniev AS. Conformation and mode of membrane interaction in cyclotides. Spatial structure of kalata B1 bound to a dodecylphosphocholine micelle. FEBS J (2008) 273: 2658-2672 [P, NA]
Simonsen SM, Sando L, Rosengren KJ, Wang CK, Colgrave ML, Daly NL, Craik DJ Alanine scanning mutagenesis of the prototypic cyclotide reveals a cluster of residues essential for bioactivity J Biol Chem (2008) 283: 9805-9813 [P, NA]
2007 Hallen HE, Luo H, Scott-Craig JS, Walton JD Gene family encoding the major toxins of lethal Amanita mushrooms Proc Natl Acad Sci U S A (2007) 104: 19097-19101 [P, NA]
Jiang S, Li P, Lee SL, Lin CY, Long YQ, Johnson MD, Dickson RB, Roller PP Design and synthesis of redox stable analogues of sunflower trypsin inhibitors (SFTI-1) on solid support, potent inhibitors of matriptase. Org Lett (2007) 9: 9-12 [P, NA]
Plan MR, Goransson U, Clark RJ, Daly NL, Colgrave ML, Craik DJ The Cyclotide Fingerprint in Oldenlandia affinis: Elucidation of Chemically Modified, Linear and Novel Macrocyclic Peptides Chembiochem (2007) 8: 1001-1011 [P, NA]
Quintyne-Walcott, S., Maxwell, A.R. and Reynolds, W.F. Crotogossamide, a cyclic nonapeptide from the latex of Croton gossypifolius Journal of natural products (2007) 70: 1374-1376 [P, NA]
Seydel P, Gruber CW, Craik DJ, Dörnenburg H Formation of cyclotides and variations in cyclotide expression in Oldenlandia affinis suspension cultures. Appl Microbiol Biotechnol. (2007) 77: 275-284 [P, NA]
Shimamura,K., Ishimizu,T., Nishimura,K., Matsubara,K., Kodama,H., Watanabe,H., Hase,S. and Ando,T. Analysis of expressed sequence tags from petunia flowers Plant Sci. (2007) 173: 495-500 [P, NA]
Svangard E, Burman R, Gunasekera S, Lovborg H, Gullbo J, Goransson U Mechanism of action of cytotoxic cyclotides: cycloviolacin O2 disrupts lipid membranes. J Nat Prod (2007) 70: 643-647 [P, NA]
Thongyoo P, Jaulent AM, Tate EW, Leatherbarrow, RJ Immobilized protease-assisted sysnthesis of engineered cysteine-knot microproteins Chembiochem (2007) 8: 1107-1109 [P, NA]
Wang CK, Colgrave ML, Gustafson KR, Ireland DC, Göransson U, Craik DJ Anti-HIV Cyclotides from the CHinese Medicinal Herb Viola yedoensis J Nat Prod (2007) 71: 47-52 [P, NA]
Wirawan RE, Swanson KM, Kleffmann T, Jack RW, Tagg JR Uberolysin: a novel cyclic bacteriocin produced by Streptococcus uberis. Microbiology (2007) 153: 1619-30 [P, NA]
2006 Cemazar M, Daly NL, Häggblad S, Lo KP, Yulyaningsih E, Craik DJ Knots in rings. The circular knotted protein Momordica cochinchinensis trypsin inhibitor-II folds via a stable two-disulfide intermediate. J Biol Chem (2006) 281(12):8224-32: 8224-8232 [P, NA]
Chen B, Colgrave ML, Wang C, Craik DJ Cycloviolacin H4, a hydrophobic cyclotide from Viola hederaceae. J Nat Prod (2006) 69: 23-8 [P, NA]
Clark RJ, Daly NL, Craik DJ Structural plasticity of the cyclic-cystine-knot framework: implications for biological activity and drug design. Biochem J (2006) 394: 85-93 [P, NA]
Daly NL, Chen YK, Foley FM, Bansal PS, Bharathi R, Clark RJ, Sommerhoff CP, Craik DJ The absolute structural requirement for a proline in the P3'-position of Bowman-Birk protease inhibitors is surmounted in the minimized SFTI-1 scaffold J Biol Chem (2006) 281: 23668-75 [P, NA]
Daly NL, Clark RJ, Plan MR, Craik DJ Kalata B8, a novel antiviral circular protein, exhibits conformational flexibility in the cystine knot motif. Biochem J (2006) 393: 619-26 [P, NA]
Guo X, Shi J, Tang Z, Cui D, Zhang Y Synthesis and biological activity of seleno sunflower trypsin inhibitor analog. Chem Biol Drug Des (2006) 68: 341-4 [P, NA]
Herrmann A, Svangard E, Claeson P, Gullbo J, Bohlin L, Goransson U Key role of glutamic acid for the cytotoxic activity of the cyclotide cycloviolacin O2. Cell Mol Life Sci (2006) 63: 235-45 [P, NA]
Ireland DC, Colgrave ML, Craik DJ A novel suite of cyclotides from Viola odorata: sequence variation and the implications for structure, function and stability. Biochem J. (2006) 400: 1-12 [P, NA]
Ireland DC, Colgrave ML, Nguyencong P, Daly NL, Craik DJ Discovery and characterization of a linear cyclotide from Viola odorata: implications for the processing of circular proteins. J Mol Biol (2006) 357: 1522-35 [P, NA]
Mongkolvisut, W., Sutthivaiyakit, S., Leutbecher, H., Mika, S., Klaiber, I., Möller, W., Rösner, H., Beifuss, U. and Conrad, J. Integerrimides A and B, cyclic heptapeptides from the latex of Jatropha integerrima Journal of natural products (2006) 69: 1435-1441 [P, NA]
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Zhao Y-R, Zhou J, Wang X-K, Wu H-M, Huang X-L, Zou C Three cyclopeptides from Stellaria delavayi Phytochemistry (1997) 46: 709-714 [P, NA]
1996 Derua R, Gustafson KR, Pannell LK Analysis of the disulfide linkage pattern in circulin A and B, HIV-inhibitory macrocyclic peptides. Biochem Biophys Res Commun (1996) 228: 632-8 [P, NA]
Horsten SFAJ, van den Berg AJJ, Kettenes-van den Bosch JJ, Leeflang BR, Labadie RP Cyclogossine A: A Novel Cyclic Heptapeptide Isolated from the Latex of Jatropha gossypifolia Planta Med (1996) 62: 46-50 [P, NA]
Morita H, Kayashita T, Shimomura M, Takeya K, Itokawa H Cyclic Peptides from Higher Plants. 24.1 Yunnanin C, a Novel Cyclic Heptapeptide from Stellaria yunnanensis J Nat Prod (1996) 59: 280-282 [P, NA]
Morita H, Kayashita T, Shishido A, Takeya K, Itokawa H, Shiro M Dichotomins A - E, new cyclic peptides from stellaria dichotoma L. var. lanceolata Bge. Tetrahedron (1996) 52: 1165-1176 [P, NA]
Morita H, Yun YS, Takeya K, Itokawa H, Shirota O A cyclic heptapeptide from Vaccaria segetalis Phytochemistry (1996) 42: 439-441 [P, NA]
Van den Berg AJJ, Horsten SFAJ, Kettenes-van den Bosch JJ, Beukelman CJ, Kroes BH, Leeflang BR, Labadie RP Podacycline A and B, two cyclic peptides in the latex of Jatropha podagrica Phytochemistry (1996) 42: 129-133 [P, NA]
1995 Itokawa H, Yun Y, Morita H, Takeya K, Yamada K Estrogen-like activity of cyclic peptides from Vaccaria segetalis extracts Planta Med (1995) 61: 561-562 [P, NA]
Itokawa H, Yun Y, Morita H, Takeya K, Yamada K Estrogen-like activity of cyclic peptides from Vaccaria segetalis extracts. Planta Med (1995) 61: 561-562 [P, NA]
Li, C., Tan, N., Lu, Y., Liang, H., Mu, Q., Zheng, H., Hao, X. and Zhou, J. Annomuricatin A, a new cyclopeptide from the seeds of Annona muricata Acta Botanica Yunnanica (1995) 17: 459-462 [P, NA]
Morita H, Kayashita T, Takeya K, Itokawa H Cyclic Peptides from Higher Plants, Part 15, Pseudostellarin H, a New Cyclic Octapeptide from Pseudostellaria heterophylla J Nat Prod (1995) 58: 943-947 [P, NA]
Morita H, Kayashita T, Takeya K, Itokawa H, Shiro M Crystal and solution forms of a cyclic heptapeptide, pseudostellarin D1) Tetrahedron (1995) 51: 12539-12548 [P, NA]
Morita H, Yun YS, Takeya K, Itokawa H, Shiro M Conformational analysis of a cyclic hexapeptide, segetalin A from Vaccaria segetalis Tetrahedron (1995) 51: 5987-6002 [P, NA]
Morita H, Yun YS, Takeya K, Itokawa H, Yamada K Segetalins B, C and D, three new cyclic peptides from Vaccaria segetalis Tetrahedron (1995) 51: 6003-6014 [P, NA]
Saether O, Craik DJ, Campbell ID, Sletten K, Juul J, Norman DG Elucidation of the primary and three-dimensional structure of the uterotonic polypeptide kalata B1. Biochemistry (1995) 34: 4147-58 [P, NA]
van den Berg AJ, Horsten SF, Kettenes-van den Bosch JJ, Kroes BH, Beukelman CJ, Leeflang BR, Labadie RP Curcacycline A--a novel cyclic octapeptide isolated from the latex of Jatropha curcas L. FEBS lett (1995) 385: 215-218 [P, NA]
Zhao Y-R, Zhou J, Wang X-K, Huang X-L, Wu H-M, Zou C Cyclopeptides from Stellaria yunnanensis Phytochemistry (1995) 40: 1453-1456 [P, NA]
1994 Gustafson KR, Sowder RC, Henderson LE, Parsons IC, Kashman Y, Cardellina JH, McMahon JB, Buckheit RB, Pannell LK, Boyd MR Circulins A and B. Novel human immunodeficiency virus (HIV)-inhibitory macrocyclic peptides from the tropical tree Chassalia parvifolia. J Am Chem Soc (1994) 116: 9338-8 [P, NA]
Kawai Y, Saito T, Toba T, Samant SK, Itoh T Isolation and characterization of a highly hydrophobic new bacteriocin (gassericin A) from Lactobacillus gasseri LA39. Biosci Biotechnol Biochem (1994) 58: 1218-21 [P, NA]
Martinez-Bueno M, Maqueda M, Galvez A, Samyn B, Van Beeumen J, Coyette J, Valdivia E Determination of the gene sequence and the molecular structure of the enterococcal peptide antibiotic AS-48. J Bacteriol (1994) 176: 6334-9 [P, NA]
Morita H, Kayashita T, Kobata H, Gonda A, Takeya K, Itokawa H Pseudostellarins D - F, new tyrosinase inhibitory cyclic peptides from Pseudostellaria heterophylla Tetrahedron (1994) 50: 9975-9982 [P, NA]
Morita H, Kayashita T, Kobata H, Gonda A, Takeya K, Itokawa H Pseudostellarins A - C, new tyrosinase inhibitory cyclic peptides from Pseudostellaria heterophylla Tetrahedron (1994) 50: 6797-6804 [P, NA]
Morita H, Kayashita T, Takeya K, Itokawa H Conformational analysis of a tyrosinase inhibitory cyclic pentapeptide, pseudostellarin A, from Pseudostellaria heterophylla Tetrahedron (1994) 50: 12599-12608 [P, NA]
Morita H, Kobata H, Takeya K, Itokawa H Pseudostellarin G, a new tyrosinase inhibitory cyclic octapeptide from Pseudostellaria heterophylla Tetrahedron Lett (1994) 35: 3563-3564 [P, NA]
Morita H, Yun YS, Takeya K, Itokawa H Segetalin A, a new cyclic hexapeptide from Vaccaria segetalis Tetrahedron Lett (1994) 35: 9593-9596 [P, NA]
Samyn B, Martinez-Bueno M, Devreese B, Maqueda M, Galvez A, Valdivia E, Coyette J, Van Beeumen J The cyclic structure of the enterococcal peptide antibiotic AS-48. FEBS Lett (1994) 352: 87-90 [P, NA]
Witherup KM, Bogusky MJ, Anderson PS, Ramjit H, Ransom RW, Wood T, Sardana M Cyclopsychotride A, a biologically active, 31-residue cyclic peptide isolated from Psychotria longipes. J Nat Prod (1994) 57: 1619-25 [P, NA]
1993 Schopke T, Hasan Agha MI, Kraft R, Otto A, Hiller K Hämolytisch aktive komponenten aus Viola tricolor L. und Viola arvensis Murray. [In German] Sci Pharm (1993) 61: 145-53 [P, NA]
Steven M. Colegate and Russell J. Molyneux Bioactive natural Products: Detection, Isolation and structural Determination CRC press (1993) : 279-317 [P, NA]
Tan N-H, Zhou J, Chen C-X, Zhao S-X Cyclopeptides from the roots of Pseudostellaria heterophylla Phytochemistry (1993) 32: 1327-1330 [P, NA]
1991 Kinoshita K, Tanaka J, Kuroda K, Koyama K, Natori S, Kinoshita T Cycloleonurinin, a Cyclic Peptide from Leonuri Fructus Chem Pharm Bull (1991) 39: 712-715 [P, NA]
Matsubara Y, Yusa T, Sawabe A, Iizuka Y, Takekuma S, Yoshida Y Structures of New Cyclic Peptides in Young Unshiu (Citrus unshiu MARCOV.), Orange (Citrus sinensis OSBECK.) and Amanatsu (Citrus natsudaidai) Peelings Agric Biol Chem (1991) 55: 2923-2929 [P, NA]
Toba T, Samant SK, Yoshioka E, Itoh T Reutericin 6, a new bacteriocin produced by Lactobacillus reuteri LA6. Lett Appl Microbiol (1991) 13: 281-6 [P, NA]
1989 Bashwira S, Hootelé C, Tourwé D, Pepermans H, Laus G, Van Binst G Cleromyrine I, a new cyclohexapeptide from clerodendrum myricoides Tetrahedron (1989) 45: 5845-5852 [P, NA]
Blasio BD, Rossi F, Benedetti E, Pavone V, Pedone C, Temussi PA, Zanotti G, Tancredi T Bioactive peptides: solid-state and solution conformation of cyclolinopeptide A J Am Chem Soc (1989) 111: 9089-9098 [P, NA]
Galvez A, Valdivia E, Martinez M, Maqueda M Bactericidal action of peptide antibiotic AS-48 against Escherichia coli K-12. Can J Microbiol (1989) 35: 318-21 [P, NA]
Kosasi S, van der Sluis WG, Boelens R, Hart LA, Labadie RP Labaditin, a novel cyclic decapeptide from the latex of Jatropha multifida L. (Euphorbiaceae): Isolation and sequence determination by means of two-dimensional NMR FEBS lett (1989) 256: 91-96 [P, NA]
1985 Galvez A, Valdivia E, Maqueda M, Montoya E Production of bacteriocin-like substances by group D streptococci of human origin. Microbios (1985) 43: 223-32 [P, NA]
1983 Goldenberg DP, Creighton TE Circular and circularly permuted forms of bovine pancreatic trypsin inhibitor. J Mol Biol (1983) 165: 407-13 [P, NA]
1978 Wieland T, Faulstich H Amatoxins, phallotoxins, phallolysin, and antamanide: the biologically active components of poisonous Amanita mushrooms. CRC Crit Rev Biochem (1978) 5: 185-260 [P, NA]
1959 Kaufmann, H.P. and Tobschirbel, A. Ãœber ein oligopeptid aus leinsamen Chemische Berichte (1959) 92: 2805-2809 [P, NA]
Levesque MP, Twigg RW, Motley T, Katari MS, Dedhia NN, O'Shaughnessy AL, Balija V, Martienssen RA, McCombie RW, Benfey P, Stevenson D (Unpublished)
Levesque MP, Twigg RW, Motley T, Katari MS, Dedhia NN, O'Shaughnessy AL, Balija V, Martienssen RA, McCombie RW, Benfey P, Stevenson D (Unpublished)
Zhang J, Shu W, Liao B (Unpublished)

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CyBase is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to CyBase, the database of cyclic proteins (http://www.cybase.org.au). For any other use please contact David Craik (d.craik@imb.uq.edu.au).

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Last updated: Monday 29 May 2023