circulin A(8) Protein Card

General Information
Name circulin A
Class Cyclotide
Technique MS
Average Mass 3151.72
Monoisotopic Mass 3149.38
m/z M+H 3151.72
ProteinType Wild type
Organism Chassalia parvifolia
Chassalia chartacea
Cyclic Yes

NOE Restraint
NOE restraints for 1BH4 [...]
Chemical Shift
Chemical shift data for ciruclin A [...]
Hemolytic activity established for kalata B1, circulin A, circulin B and cyclopsychotride A [...]Tam JP et al. (1999) Proc Natl Acad Sci U S A 96:8913-8
Kalata B1, circulin A and B and cyclopsychotride shown to possess some anti-bacterial activity. [...]Tam JP et al. (1999) Proc Natl Acad Sci U S A 96:8913-8
Circulin A and B shown to possess antiviral cytoprotective activity. [...]Gustafson KR et al. (1994) J Am Chem Soc 116:9338-8

Trabi M, Craik DJ (2004) Tissue-specific expression of head-to-tail cyclized miniproteins in Violaceae and structure determination of the root cyclotide Viola hederacea root cyclotide1. Plant Cell 16:2204-16
Gustafson KR, Sowder RC, Henderson LE, Parsons IC, Kashman Y, Cardellina JH, McMahon JB, Buckheit RB, Pannell LK, Boyd MR (1994) Circulins A and B. Novel human immunodeficiency virus (HIV)-inhibitory macrocyclic peptides from the tropical tree Chassalia parvifolia. J Am Chem Soc 116:9338-8
Tam JP, Lu YA, Yang JL, Chiu KW (1999) An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides. Proc Natl Acad Sci U S A 96:8913-8
Derua R, Gustafson KR, Pannell LK (1996) Analysis of the disulfide linkage pattern in circulin A and B, HIV-inhibitory macrocyclic peptides. Biochem Biophys Res Commun 228:632-8
Nguyen,G.K., Lim,W.H., Nguyen,P.Q. and Tam,J.P. (2012) Novel cyclotides and uncyclotides with highly shortened precursors from Chassalia chartacea and effects of methionine oxidation on bioactivities. J. Biol. Chem. 287:17598-17607

Nucleic acids
Structure circulin A
Links GenBank P56871.2
SwissProt P56871