varv peptide F(64) Protein Card

General Information
Name varv peptide F
Sequence GVPICGETCTLGTCYTAGCSCSWPVCTRN
Class Cyclotide
Technique MS
Average Mass 2959.37
Monoisotopic Mass 2957.17
m/z M+H 2959.37
ProteinType Wild type
Parent
Organism Viola tricolor
Viola arvensis
Notes
Cyclic Yes

Assay
Cancer Cell Toxicity
All three cyclotides, varv A, varv F, and cycloviolacin O2, exhibited strong cytotoxic activities, which varied in a dose-dependent manner. [...]Lindholm P et al. (2002) Mol Cancer Ther 1:365-369

References
Goransson U, Luijendijk T, Johansson S, Bohlin L, Claeson P (1999) Seven novel macrocyclic polypeptides from Viola arvensis. J Nat Prod 62:283-6
Lindholm P, Goransson U, Johansson S, Claeson P, Gullbo J, Larsson R, Bohlin L, Backlund A (2002) Cyclotides: a novel type of cytotoxic agents. Mol Cancer Ther 1:365-369
Tang J, Wang CK, Pan X, Yan H, Zeng G, Xu W, He W, Daly NL, Craik DJ, Tan N (2010) Isolation and characterization of cytotoxic cyclotides from Viola tricolor. Peptides 31:1434-1440
Hellinger,R., Koehbach,J., Soltis,D.E., Carpenter,E.J., Wong,G.K. and Gruber,C.W. (2015) Peptidomics of Circular Cysteine-Rich Plant Peptides: Analysis of the Diversity of Cyclotides from Viola tricolor by Transcriptome and Proteome Mining. J. Proteome Res. 14:4851-4862

Cross-references
Nucleic acids
Structure Solution Structure of varv F
Crystal structure of the cyclotide varv F
Links GenBank P58451.1
SwissProt P58451

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