psyle E(556) Protein Card

General Information
Name psyle E
Sequence GVIPCGESCVFIPCISSVLGCSCKNKVCYRD
Class Cyclotide
Technique MS,Amino acid analysis
Average Mass 3256.85
Monoisotopic Mass 3254.45
m/z M+H 3256.85
ProteinType Wild type
Parent
Organism Psychotria leptothyrsa
Notes
Cyclic Yes

Assay
Cancer Cell Toxicity
Nonclonogenic fluorometric microculture cytotoxicity assay was performed on psyle A, C and E using U-937 GTB human lymphoma tumor cell line. [...]Gerlach SL et al. (2010) J Nat Prod 73:1207-1213
Psyle A, psyle C, psyle E and cycloviolacin O2 shown to possess cytotoxic activity in cancer cells. [...]Gerlach SL et al. (2010) Biopolymers 94:617-625

References
Gerlach SL, Burman R, Bohlin L, Mondal D, Göransson U (2010) Isolation, characterization, and bioactivity of cyclotides from the Micronesian plant Psychotria leptothyrsa J Nat Prod 73:1207-1213
Gerlach SL, Rathinakumar R, Chakravarty G, Göransson U, Wimley WC, Darwin SP, Mondal D (2010) Anticancer and chemosensitizing abilities of cycloviolacin 02 from Viola odorata and psyle cyclotides from Psychotria leptothyrsa. Biopolymers 94:617-625
Fahradpour, M., Keov, P., Tognola, C., Perez-Santamarina, E., McCormick, P.J., Ghassempour, A. and Gruber, C.W. (2017) Cyclotides Isolated from an Ipecac Root Extract Antagonize the Corticotropin Releasing Factor Type 1 Receptor Frontiers in pharmacology 8:616-0

Cross-references
Nucleic acids
Structure
Links

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