psyle A(552) Protein Card

General Information
Name psyle A
Sequence GIACGESCVFLGCFIPGCSCKSKVCYFN
Class Cyclotide
Technique Amino acid analysis,MS
Average Mass 2912.44
Monoisotopic Mass 2910.21
m/z M+H 2912.44
ProteinType Wild type
Parent
Organism Psychotria leptothyrsa
Notes
Cyclic Yes

Assay
Cancer Cell Toxicity
Psyle A, psyle C, psyle E and cycloviolacin O2 shown to possess cytotoxic activity in cancer cells. [...]Gerlach SL et al. (2010) Biopolymers 94:617-625
Nonclonogenic fluorometric microculture cytotoxicity assay was performed on psyle A, C and E using U-937 GTB human lymphoma tumor cell line. [...]Gerlach SL et al. (2010) J Nat Prod 73:1207-1213

References
Gerlach SL, Burman R, Bohlin L, Mondal D, Göransson U (2010) Isolation, characterization, and bioactivity of cyclotides from the Micronesian plant Psychotria leptothyrsa J Nat Prod 73:1207-1213
Gerlach SL, Rathinakumar R, Chakravarty G, Göransson U, Wimley WC, Darwin SP, Mondal D (2010) Anticancer and chemosensitizing abilities of cycloviolacin 02 from Viola odorata and psyle cyclotides from Psychotria leptothyrsa. Biopolymers 94:617-625

Cross-references
Nucleic acids
Structure
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