[Glu(Me)]cyO2(236) Protein Card

General Information
Name [Glu(Me)]cyO2
Sequence GIPCGXSCVWIPCISSAIGCSCKSKVCYRN
Class Cyclotide
Average Mass NA
Monoisotopic Mass 0
m/z M+H 0
ProteinType Mutant
Parent cycloviolacin O2
Organism Synthetic
Notes Modified glutamic acid
Cyclic Yes

Assay
Cancer Cell Toxicity
Glutamic acid mutant had reduced activity [...]Herrmann A et al. (2006) Cell Mol Life Sci 63:235-45
Nematocidal
A range of natural variants were selected based on net charge and/or hydrophobicity and were tested alongside the prototypic cyclotide kB1 in larval development assays with H. contortus and T. colubriformis. [...]Colgrave ML et al. (2008) Chembiochem 9:1939-1945

References
Herrmann A, Svangard E, Claeson P, Gullbo J, Bohlin L, Goransson U (2006) Key role of glutamic acid for the cytotoxic activity of the cyclotide cycloviolacin O2. Cell Mol Life Sci 63:235-45

Cross-references
Nucleic acids
Structure
Links

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