SFTI-3(219) Protein Card

General Information
Name SFTI-3
Sequence GRCTKSIPPICFPD
Class BBI-like trypsin inhibitor
Average Mass 1513.79
Monoisotopic Mass 1512.72
m/z M+H 1513.73
ProteinType Mutant
Parent SFTI-1
Organism Synthetic
Notes Dicarba analogue of disulfide bond. Olefin reduced.
Cyclic Yes

Assay
Protease inhibition
Matriptase inhibitory activity of SFTI-2 is 25-fold less potent than native, while SFTI-3 exhibits similar potency. [...]Jiang S et al. (2007) Org Lett 9:9-12

References
Jiang S, Li P, Lee SL, Lin CY, Long YQ, Johnson MD, Dickson RB, Roller PP (2007) Design and synthesis of redox stable analogues of sunflower trypsin inhibitors (SFTI-1) on solid support, potent inhibitors of matriptase. Org Lett 9:9-12

Cross-references
Nucleic acids
Structure
Links

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