[F12A]SFTI-1(213) Protein Card

General Information
Name [F12A]SFTI-1
Sequence GRCTKSIPPICAPD
Class BBI-like trypsin inhibitor
Average Mass 1437.69
Monoisotopic Mass 1436.69
m/z M+H 1437.7
ProteinType Mutant
Parent SFTI-1
Organism Synthetic
Notes Alanine mutant
Cyclic Yes

Assay
Protease inhibition
12 SFTI alanine mutants were tested for inhibitory activity against bovine trypsin. K5A mutant shows the weakest activity. [...]Daly NL et al. (2006) J Biol Chem 281:23668-75

References
Daly NL, Chen YK, Foley FM, Bansal PS, Bharathi R, Clark RJ, Sommerhoff CP, Craik DJ (2006) The absolute structural requirement for a proline in the P3'-position of Bowman-Birk protease inhibitors is surmounted in the minimized SFTI-1 scaffold J Biol Chem 281:23668-75

Cross-references
Nucleic acids
Structure
Links

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