[I11G]kB5(1941) Protein Card

General Information
Name [I11G]kB5
Sequence GTPCGESCVYGPCISGVIGCSCTDKVCYLN
Class Cyclotide
Average Mass 3005.43
Monoisotopic Mass 3003.2
m/z M+H 3005.43
ProteinType Modified Wild Type
Parent kalata B5
Organism Synthetic
Notes
Cyclic Yes

Assay
Membrane Binding Assay
[I11L] mutants of cyO2, cyO9, hyen D and kalata B5 exhibited equipotent binding to the POPC/POPE(80:20) model membrane compared to their wild-type counterparts whereas the [I11G] mutants showed no binding or weak affinity to membranes. [...]Huang,Y.H. et al. (2021) Molecules 26:0-0
Cancer Cell Toxicity
Cytotoxicity of cyO2, cyO9, hyen D and kB5 and their mutants on HeLa cells. [...]Huang,Y.H. et al. (2021) Molecules 26:0-0

References
Huang,Y.H., Du,Q., Jiang,Z., King,G.J., Collins,B.M. and Craik,D.J. (2021) Enabling Efficient Folding and High-Resolution Crystallographic Analysis of Bracelet Cyclotides. Molecules 26:0-0

Cross-references
Nucleic acids
Structure
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