kalata b1-2(15) Protein Card

General Information
Name kalata b1-2
Sequence GTCNTPGCTCSWPVCTRNGLPVCGETCVG
Class Cyclotide
Average Mass 2910.30
Monoisotopic Mass 2908.16
m/z M+H 2909.17
ProteinType Acyclic permutant
Parent kalata B1
Organism Synthetic
Notes Acyclic permutant in loop 2
Cyclic No

Assay
Hemolytic
Hemolytic activity for established for kalata B1 but not acyclic permutants [...]Daly NL and Craik DJ (2000) J Biol Chem 275:19068-75
Anti-HIV
Anti-HIV activity shown for kalata B1 but not for acyclic permutants. [...]Daly NL et al. (2004) FEBS Lett 574:69-72

References
Daly NL, Gustafson KR, Craik DJ (2004) The role of the cyclic peptide backbone in the anti-HIV activity of the cyclotide kalata B1. FEBS Lett 574:69-72
Daly NL, Craik DJ (2000) Acyclic permutants of naturally occurring cyclic proteins. Characterization of cystine knot and beta-sheet formation in the macrocyclic polypeptide kalata B1. J Biol Chem 275:19068-75

Cross-references
Nucleic acids
Structure
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