Parigidin-br3(1313) Protein Card

General Information
Name Parigidin-br3
Alternative name(s) PBR3
Sequence PSPCGESCVFIPCISALIGCSCKNKVCYR
Class Cyclotide
Technique MS
Average Mass 3072.66
Monoisotopic Mass 3070.38
m/z M+H 3072.66
ProteinType Wild type
Parent
Organism Palicourea rigida
Notes
Cyclic No

Assay
Cancer Cell Toxicity
Parigidin-br3 showed cytotoxic activity against MCF-7 (breast cancer) and CACO2 (colorectal adenocarcinoma) cells, with IC50 values of ∼2.5 μM and less than 10% hemolytic activity. [...]Pinto et al. (2016) Journal of natural products 79:2767-2773

References
Pinto, M.F., Silva, O.N., Viana, J.C., Porto, W.F., Migliolo, L., B. da Cunha, N., Gomes Jr, N., Fensterseifer, I.C., Colgrave, M.L., Craik, D.J. and Dias, S.C (2016) Characterization of a Bioactive Acyclotide from Palicourea rigida Journal of natural products 79:2767-2773

Cross-references
Nucleic acids
Structure
Links

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