MCo-AT1-7(1293) Protein Card

General Information
Name MCo-AT1-7
Sequence GGVCPKILQRCRRDSDCPGACICRGNGYCGSGEIYVRX
Class Squash trypsin inhibitor
Average Mass 3939.51
Monoisotopic Mass 3936.76
m/z M+H 3939.51
ProteinType Grafted
Parent MCoTI-II
Organism Synthetic
Notes The last C-terminal residue X represents L-2,3-diaminopropionic acid.
Cyclic Yes

Assay
Enzymatic Digest
MCo-AT1-7 showed high stability in human serum, which was more stable than AT1-7 and linear MCo-AT1-7. MCo-AT1-7 was able to increase the intracellular concentration of NO as AT1-7 but not MCOTI-II. [...]Aboye et al. (2016) Molecules 21:152-0

References
Aboye, T., Meeks, C.J., Majumder, S., Shekhtman, A., Rodgers, K. and Camarero, J.A (2016) Design of a MCoTI-based cyclotide with angiotensin (1-7)-like activity Molecules 21:152-0

Cross-references
Nucleic acids
Structure
Links

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