Src homology 3 domain (Crkcirc-wt)(122) Protein Card

General Information
Name Src homology 3 domain (Crkcirc-wt)
Sequence CEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAE
DSEGKRGMIPVPYVEKYG
Class Cyclised linear proteins
Average Mass 6876.65
Monoisotopic Mass 6872.31
m/z M+H 6873.31
ProteinType Cyclic permutant
Parent
Organism Synthetic
Notes
Cyclic Yes

Assay
Ligand binding affinity
Head-to-Tail cyclization improved biological activity of Src homology domain of c-Crk. [...]Camarero JA and Muir TW (1999) J Am Chem Soc 121:5597-8

References
Camarero JA, Fushman D, Sato S, Giriat I, Cowburn D, Raleigh DP, Muir TW (2001) Rescuing a destabilized protein fold through backbone cyclization. J Mol Biol 308:1045-62
Camarero JA, Muir TW (1999) Biosynthesis of a Head-to-Tail Cyclized Protein with Improved Biological Activity. J Am Chem Soc 121:5597-8

Cross-references
Nucleic acids
Structure
Links

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