caripe 11(1134) Protein Card

General Information
Name caripe 11
Sequence GVIPCGESCVFIPCISTVIGCSCKKKVCYRN
Class Cyclotide
Technique MS
Average Mass 3283.96
Monoisotopic Mass 3281.53
m/z M+H 3283.96
ProteinType Wild type
Parent
Organism Carapichea ipecacuanha
Notes Sequence confirmed by MS (Fahradpour et al., 2017). Caripe 11 is a partial agonist of the cholecystokinin-2 receptor (Emax = 71%) with a moderate potency of 8.5±1.7 uM, while the potency of the full agonist cholecystokinin-8 is 11.5 nM (Taghizadeh et al., 2022).
Cyclic Yes

Assay
Cell viability assay
Caripe 11 had no major influence on viability against HEK293 cells. [...]Taghizadeh,M.S. et al. (2022) Sci Rep 12:9215-0

References
Fahradpour, M., Keov, P., Tognola, C., Perez-Santamarina, E., McCormick, P.J., Ghassempour, A. and Gruber, C.W. (2017) Cyclotides Isolated from an Ipecac Root Extract Antagonize the Corticotropin Releasing Factor Type 1 Receptor Frontiers in pharmacology 8:616-0
Taghizadeh,M.S., Retzl,B., Muratspahi?,E., Trenk,C., Casanova,E., Moghadam,A., Afsharifar,A., Niazi,A., and Gruber,C.W. (2022) Discovery of the cyclotide caripe 11 as a ligand of the cholecystokinin-2 receptor. Sci Rep 12:9215-0

Cross-references
Nucleic acids
Structure
Links

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