(167) Assay Card

General Information
Summary Human beta-coagulation factor XIIa (FXIIa) inhibitory activity (Ki) of chemically synthesized MCoTI-II and acyclic or cyclic MCoFx1-5
Condition Refer "Protease inhibition assays" described in the method part (Liu et al., 2021).
Result MCoTI-II: 129+/-9 nM; MCoFx1: 0.73+/-0.20 nM; cMCoFx1: 0.37+/-0.04 nM; MCoFx2: 73+/-3 nM; cMCoFx2: 12.0+/-0.7 nM; MCoFx3: 525+/-30 nM; cMCoFx3: 75+/-3 nM; MCoFx4: 17.0+/-0.9 nM; cMCoFx4: 5.5+/-0.5 nM; MCoFx5: 106+/-7 nM; cMCoFx5: 207+/-9 nM
AssayType Protease inhibition

References
Liu W, de Veer SJ, Huang YH, Sengoku T, Okada C, Ogata K, Zdenek CN, Fry BG, Swedberg JE, Passioura T, Craik DJ, Suga H. (2021) An Ultrapotent and Selective Cyclic Peptide Inhibitor of Human beta-Factor XIIa in a Cyclotide Scaffold J Am Chem Soc 143:18481-18489

Cross-references
Proteins Assayed cMCoFx5
MCoFx5
cMCoFx4
MCoFx4
cMCoFx3
MCoFx3
cMCoFx2
MCoFx2
cMCoFx1
MCoFx1