Protein List

Found 55 entries.


ID Name Class Organism Assay Summary
45 circulin B Cyclotide Chassalia parvifolia Hemolytic activity established for kalata B1, circulin A, circulin B and cyclopsychotride A [...]
8 circulin A Cyclotide Chassalia parvifolia
Chassalia chartacea
Hemolytic activity established for kalata B1, circulin A, circulin B and cyclopsychotride A [...]
241 kalata B1 nfk Cyclotide Oldenlandia affinis Both kalata B1 oia and B1 nfk exhibited no haemolytic activity [...]
240 kalata B1 oia Cyclotide Oldenlandia affinis Both kalata B1 oia and B1 nfk exhibited no haemolytic activity [...]
168 kalata B8 Cyclotide Oldenlandia affinis Kalata B8 did not display haemolytic activity. [...]
32 cyclopsychotride A Cyclotide Psychotria longipes Hemolytic activity established for kalata B1, circulin A, circulin B and cyclopsychotride A [...]
459 [E7A]kalata B1 Cyclotide Synthetic Substitution of certain residues of kalata B1 to alanine result in loss of hemolytic activity. Residues in loops 1 and 3 along with a few other isolated residues strongly affect activity. [...]
460 [T8A]kalata B1 Cyclotide Synthetic Substitution of certain residues of kalata B1 to alanine result in loss of hemolytic activity. Residues in loops 1 and 3 along with a few other isolated residues strongly affect activity. [...]
461 [V10A]kalata B1 Cyclotide Synthetic Substitution of certain residues of kalata B1 to alanine result in loss of hemolytic activity. Residues in loops 1 and 3 along with a few other isolated residues strongly affect activity. [...]
457 [V4A]kalata B1 Cyclotide Synthetic Substitution of certain residues of kalata B1 to alanine result in loss of hemolytic activity. Residues in loops 1 and 3 along with a few other isolated residues strongly affect activity. [...]
454 [G1A]kalata B1 Cyclotide Synthetic Substitution of certain residues of kalata B1 to alanine result in loss of hemolytic activity. Residues in loops 1 and 3 along with a few other isolated residues strongly affect activity. [...]
455 [L2A]kalata B1 Cyclotide Synthetic Substitution of certain residues of kalata B1 to alanine result in loss of hemolytic activity. Residues in loops 1 and 3 along with a few other isolated residues strongly affect activity. [...]
456 [P3A]kalata B1 Cyclotide Synthetic Substitution of certain residues of kalata B1 to alanine result in loss of hemolytic activity. Residues in loops 1 and 3 along with a few other isolated residues strongly affect activity. [...]
458 [G6A]kalata B1 Cyclotide Synthetic Substitution of certain residues of kalata B1 to alanine result in loss of hemolytic activity. Residues in loops 1 and 3 along with a few other isolated residues strongly affect activity. [...]
462 [G11A]kalata B1 Cyclotide Synthetic Substitution of certain residues of kalata B1 to alanine result in loss of hemolytic activity. Residues in loops 1 and 3 along with a few other isolated residues strongly affect activity. [...]
473 [V25A]kalata B1 Cyclotide Synthetic Substitution of certain residues of kalata B1 to alanine result in loss of hemolytic activity. Residues in loops 1 and 3 along with a few other isolated residues strongly affect activity. [...]
470 [S22A]kalata B1 Cyclotide Synthetic Substitution of certain residues of kalata B1 to alanine result in loss of hemolytic activity. Residues in loops 1 and 3 along with a few other isolated residues strongly affect activity. [...]
474 [T27A]kalata B1 Cyclotide Synthetic Substitution of certain residues of kalata B1 to alanine result in loss of hemolytic activity. Residues in loops 1 and 3 along with a few other isolated residues strongly affect activity. [...]
475 [R28A]kalata B1 Cyclotide Synthetic Substitution of certain residues of kalata B1 to alanine result in loss of hemolytic activity. Residues in loops 1 and 3 along with a few other isolated residues strongly affect activity. [...]
476 [N29A]kalata B1 Cyclotide Synthetic Substitution of certain residues of kalata B1 to alanine result in loss of hemolytic activity. Residues in loops 1 and 3 along with a few other isolated residues strongly affect activity. [...]
469 [T20A]kalata B1 Cyclotide Synthetic Substitution of certain residues of kalata B1 to alanine result in loss of hemolytic activity. Residues in loops 1 and 3 along with a few other isolated residues strongly affect activity. [...]
468 [G18A]kalata B1 Cyclotide Synthetic Substitution of certain residues of kalata B1 to alanine result in loss of hemolytic activity. Residues in loops 1 and 3 along with a few other isolated residues strongly affect activity. [...]
464 [T13A]kalata B1 Cyclotide Synthetic Substitution of certain residues of kalata B1 to alanine result in loss of hemolytic activity. Residues in loops 1 and 3 along with a few other isolated residues strongly affect activity. [...]
463 [G12A]kalata B1 Cyclotide Synthetic Substitution of certain residues of kalata B1 to alanine result in loss of hemolytic activity. Residues in loops 1 and 3 along with a few other isolated residues strongly affect activity. [...]
465 [N15A]kalata B1 Cyclotide Synthetic Substitution of certain residues of kalata B1 to alanine result in loss of hemolytic activity. Residues in loops 1 and 3 along with a few other isolated residues strongly affect activity. [...]
466 [T16A]kalata B1 Cyclotide Synthetic Substitution of certain residues of kalata B1 to alanine result in loss of hemolytic activity. Residues in loops 1 and 3 along with a few other isolated residues strongly affect activity. [...]
467 [P17A]kalata B1 Cyclotide Synthetic Substitution of certain residues of kalata B1 to alanine result in loss of hemolytic activity. Residues in loops 1 and 3 along with a few other isolated residues strongly affect activity. [...]
235 [W19K, P20N, V21K]-kalata B1 Cyclotide Synthetic Both [P20D/V21K]kalata B1 and [W19K/P20N/V21K]kalata B1 exhibited no haemolytic activity. Kalata B1 exhibited mild haemolytic activity. [...]
234 [P20D,V21K]-kalata B1 Cyclotide Synthetic Both [P20D/V21K]kalata B1 and [W19K/P20N/V21K]kalata B1 exhibited no haemolytic activity. Kalata B1 exhibited mild haemolytic activity. [...]
16 kalata b1-3 Cyclotide Synthetic Hemolytic activity for established for kalata B1 but not acyclic permutants [...]
20 kalata b1-6b Cyclotide Synthetic Hemolytic activity for established for kalata B1 but not acyclic permutants [...]
13 Ac-[desGly]-KB1-Am Cyclotide Synthetic Kalata B1 showed concentration dependent erythrocyte lysis. [...]
14 kalata b1-1 Cyclotide Synthetic Hemolytic activity for established for kalata B1 but not acyclic permutants [...]
22 des(24-28)kB1 Cyclotide Synthetic Resistance to enzymatic digest shown for kalata B1 and acyclic permutants. Reduced protein was susceptible. [...]
9 N-KB1-C Cyclotide Synthetic Kalata B1 showed concentration dependent erythrocyte lysis. [...]
12 Ac-KB1-Am Cyclotide Synthetic Kalata B1 showed concentration dependent erythrocyte lysis. [...]
19 kalata b1-6a Cyclotide Synthetic Hemolytic activity for established for kalata B1 but not acyclic permutants [...]
10 Ac-KB1-C Cyclotide Synthetic Kalata B1 showed concentration dependent erythrocyte lysis. [...]
11 N-KB1-Am Cyclotide Synthetic Kalata B1 showed concentration dependent erythrocyte lysis. [...]
15 kalata b1-2 Cyclotide Synthetic Hemolytic activity for established for kalata B1 but not acyclic permutants [...]
18 kalata b1-5 Cyclotide Synthetic Hemolytic activity for established for kalata B1 but not acyclic permutants [...]
17 kalata b1-4 Cyclotide Synthetic Hemolytic activity for established for kalata B1 but not acyclic permutants [...]
351 cycloviolacin Y5 Cyclotide Viola baoshanensis
Viola yedoensis
Cycloviolacins Y4 and Y5 are the most hemolytic of the new cyclotides, both being more potent than the prototypic cyclotide kalata B1. By contrast, cycloviolacin Y1 is substantially less active than all of the other cyclotides tested. [...]
169 cycloviolacin H4 Cyclotide Viola hederacea Cycloviolacin H4 has potent haemolytic activity compared to kalata B1 [...]
184 cycloviolacin O24 Cyclotide Viola odorata At a concentration of 25 ºM, a more than 6-fold difference exists between the most hemolyticcyclotide, cycloviolacin O24 (~75% hemolysis), and the least hemolytic cyclotide cycloviolacin O14 (~11% hemolysis). The sensitivity of hemolytic activity to variations in the peptide sequence is evident when comparing cycloviolacin O2 and O13. Here, the only sequence deviation is a single residue substitution of a serine in loop 3 of O2 (HD50 ~36 ºM) to an alanine in the homologous position in O13 (HD50 ~11 ºM). The loss of this single hydroxy group changes the HD50 more than three-fold. [...]
175 cycloviolacin O15 Cyclotide Viola odorata At a concentration of 25 ºM, a more than 6-fold difference exists between the most hemolyticcyclotide, cycloviolacin O24 (~75% hemolysis), and the least hemolytic cyclotide cycloviolacin O14 (~11% hemolysis). The sensitivity of hemolytic activity to variations in the peptide sequence is evident when comparing cycloviolacin O2 and O13. Here, the only sequence deviation is a single residue substitution of a serine in loop 3 of O2 (HD50 ~36 ºM) to an alanine in the homologous position in O13 (HD50 ~11 ºM). The loss of this single hydroxy group changes the HD50 more than three-fold. [...]
174 cycloviolacin O14 Cyclotide Viola odorata At a concentration of 25 ºM, a more than 6-fold difference exists between the most hemolyticcyclotide, cycloviolacin O24 (~75% hemolysis), and the least hemolytic cyclotide cycloviolacin O14 (~11% hemolysis). The sensitivity of hemolytic activity to variations in the peptide sequence is evident when comparing cycloviolacin O2 and O13. Here, the only sequence deviation is a single residue substitution of a serine in loop 3 of O2 (HD50 ~36 ºM) to an alanine in the homologous position in O13 (HD50 ~11 ºM). The loss of this single hydroxy group changes the HD50 more than three-fold. [...]
170 cycloviolacin O13 Cyclotide Viola odorata At a concentration of 25 ºM, a more than 6-fold difference exists between the most hemolyticcyclotide, cycloviolacin O24 (~75% hemolysis), and the least hemolytic cyclotide cycloviolacin O14 (~11% hemolysis). The sensitivity of hemolytic activity to variations in the peptide sequence is evident when comparing cycloviolacin O2 and O13. Here, the only sequence deviation is a single residue substitution of a serine in loop 3 of O2 (HD50 ~36 ºM) to an alanine in the homologous position in O13 (HD50 ~11 ºM). The loss of this single hydroxy group changes the HD50 more than three-fold. [...]
37 kalata S Cyclotide Viola odorata
Oldenlandia affinis
Viola tricolor
Viola arvensis
Viola baoshanensis
Viola yedoensis
Viola biflora
Viola philippica
Viola ignobilis
Cycloviolacins Y4 and Y5 are the most hemolytic of the new cyclotides, both being more potent than the prototypic cyclotide kalata B1. By contrast, cycloviolacin Y1 is substantially less active than all of the other cyclotides tested. [...]
At a concentration of 25 ºM, a more than 6-fold difference exists between the most hemolyticcyclotide, cycloviolacin O24 (~75% hemolysis), and the least hemolytic cyclotide cycloviolacin O14 (~11% hemolysis). The sensitivity of hemolytic activity to variations in the peptide sequence is evident when comparing cycloviolacin O2 and O13. Here, the only sequence deviation is a single residue substitution of a serine in loop 3 of O2 (HD50 ~36 ºM) to an alanine in the homologous position in O13 (HD50 ~11 ºM). The loss of this single hydroxy group changes the HD50 more than three-fold. [...]
1 kalata B1 Cyclotide Viola odorata
Oldenlandia affinis
Viola tricolor
Viola baoshanensis
Viola yedoensis
Viola philippica
Substitution of certain residues of kalata B1 to alanine result in loss of hemolytic activity. Residues in loops 1 and 3 along with a few other isolated residues strongly affect activity. [...]
Cycloviolacins Y4 and Y5 are the most hemolytic of the new cyclotides, both being more potent than the prototypic cyclotide kalata B1. By contrast, cycloviolacin Y1 is substantially less active than all of the other cyclotides tested. [...]
Both kalata B1 oia and B1 nfk exhibited no haemolytic activity [...]
Cycloviolacin H4 has potent haemolytic activity compared to kalata B1 [...]
Both [P20D/V21K]kalata B1 and [W19K/P20N/V21K]kalata B1 exhibited no haemolytic activity. Kalata B1 exhibited mild haemolytic activity. [...]
Tricyclon A has minimal haemolytic activity [...]
At a concentration of 25 ºM, a more than 6-fold difference exists between the most hemolyticcyclotide, cycloviolacin O24 (~75% hemolysis), and the least hemolytic cyclotide cycloviolacin O14 (~11% hemolysis). The sensitivity of hemolytic activity to variations in the peptide sequence is evident when comparing cycloviolacin O2 and O13. Here, the only sequence deviation is a single residue substitution of a serine in loop 3 of O2 (HD50 ~36 ºM) to an alanine in the homologous position in O13 (HD50 ~11 ºM). The loss of this single hydroxy group changes the HD50 more than three-fold. [...]
Hemolytic activity established for kalata B1, circulin A, circulin B and cyclopsychotride A [...]
Hemolytic activity for established for kalata B1 but not acyclic permutants [...]
172 violacin A Cyclotide Viola odorata
Psychotria leptothyrsa
Violacin A showed markedly decreased hemolytic activity relative to the prototypic cyclotide kalata B1 [...]
21 cycloviolacin O2 Cyclotide Viola odorata
Viola biflora
Viola philippica
At a concentration of 25 ºM, a more than 6-fold difference exists between the most hemolyticcyclotide, cycloviolacin O24 (~75% hemolysis), and the least hemolytic cyclotide cycloviolacin O14 (~11% hemolysis). The sensitivity of hemolytic activity to variations in the peptide sequence is evident when comparing cycloviolacin O2 and O13. Here, the only sequence deviation is a single residue substitution of a serine in loop 3 of O2 (HD50 ~36 ºM) to an alanine in the homologous position in O13 (HD50 ~11 ºM). The loss of this single hydroxy group changes the HD50 more than three-fold. [...]
7 tricyclon A Cyclotide Viola tricolor
Viola arvensis
Tricyclon A has minimal haemolytic activity [...]
347 cycloviolacin Y1 Cyclotide Viola yedoensis Cycloviolacins Y4 and Y5 are the most hemolytic of the new cyclotides, both being more potent than the prototypic cyclotide kalata B1. By contrast, cycloviolacin Y1 is substantially less active than all of the other cyclotides tested. [...]
350 cycloviolacin Y4 Cyclotide Viola yedoensis Cycloviolacins Y4 and Y5 are the most hemolytic of the new cyclotides, both being more potent than the prototypic cyclotide kalata B1. By contrast, cycloviolacin Y1 is substantially less active than all of the other cyclotides tested. [...]