Protein List

Found 32 entries.


ID Name Class Organism Assay Summary
21 cycloviolacin O2 Cyclotide Viola odorata
Viola baoshanensis
Viola biflora
Viola philippica
Viola uliginosa
Studies using calcein assay and HeLa cells showed that at 10 uM, the increase in calcein leakage is very rapid. [...]
Psyle A, psyle C, psyle E and cycloviolacin O2 shown to possess cytotoxic activity in cancer cells. [...]
Glutamic acid mutant had reduced activity [...]
Cycloviolacin O2 showed antitumor effects are minor or absent at tolerable (sublethal) doses, and cycloviolacin O2 has a very abrupt in vivo toxicity profile, with lethality after single injection at 2 mg/kg, but no signs of discomfort to the animals at 1.5 mg/kg. Repeated dosing of 1 mg/kg gave a local-inflammatory reaction at the site of injection after 2–3 days; lower doses were without complications. [...]
Cell viability and morphology studies on the human lymphoma cell line U-937 GTB showed that cells exposed to cycloviolacin O2 displayed disintegrated cell membranes within 5 min. [...]
All three cyclotides, varv A, varv F, and cycloviolacin O2, exhibited strong cytotoxic activities, which varied in a dose-dependent manner. [...]
27 cycloviolacin O8 Cyclotide Viola odorata
Viola baoshanensis
Viola adunca
Viola uliginosa
Cycloviolacin O8 showed micromolar anticancer activity against PC-3 prostate, MDA-MB-231 breast, and OVCAR-3 ovarian cancer cell lines and antifungal activity against the agricultural pathogenFusarium graminearum. [...]
36 vitri A Cyclotide Viola tricolor
Viola biflora
Psychotria leptothyrsa
Vitri A, varv A and varv E shown to possess cytotoxic activity in cancer cells. [...]
37 kalata S Cyclotide Viola odorata
Oldenlandia affinis
Viola tricolor
Viola arvensis
Viola baoshanensis
Viola yedoensis
Viola biflora
Viola philippica
Viola ignobilis
Viola uliginosa
Viola sumatrana Miq
Vitri A, varv A and varv E shown to possess cytotoxic activity in cancer cells. [...]
All three cyclotides, varv A, varv F, and cycloviolacin O2, exhibited strong cytotoxic activities, which varied in a dose-dependent manner. [...]
38 cycloviolacin O12 Cyclotide Viola tricolor
Viola arvensis
Viola baoshanensis
Viola yedoensis
Viola tianshanica
Viola abyssinica
Viola philippica
Vitri A, varv A and varv E shown to possess cytotoxic activity in cancer cells. [...]
64 varv peptide F Cyclotide Viola tricolor
Viola arvensis
All three cyclotides, varv A, varv F, and cycloviolacin O2, exhibited strong cytotoxic activities, which varied in a dose-dependent manner. [...]
236 [Glu(Me)]cyO2 Cyclotide Synthetic Glutamic acid mutant had reduced activity [...]
237 [Lys(Ac)]2cyO2 Cyclotide Synthetic Glutamic acid mutant had reduced activity [...]
238 [Arg(CHD)]cyO2 Cyclotide Synthetic Glutamic acid mutant had reduced activity [...]
239 ([Lys(Ac)]2[Arg(CHD)])cyO2 Cyclotide Synthetic Glutamic acid mutant had reduced activity [...]
355 vibi D Cyclotide Viola biflora vibi D, E, G and H were analysed using fluorometric microculture cytotoxicity assay using a lymphoma cell line. The IC50 values ranged between 0.96 and 5.0 uM for vibi E, G and H, and vibi D was not cytotoxic at 30 uM. [...]
356 vibi E Cyclotide Viola biflora vibi D, E, G and H were analysed using fluorometric microculture cytotoxicity assay using a lymphoma cell line. The IC50 values ranged between 0.96 and 5.0 uM for vibi E, G and H, and vibi D was not cytotoxic at 30 uM. [...]
358 vibi G Cyclotide Viola tricolor
Viola biflora
Psychotria leptothyrsa
vibi D, E, G and H were analysed using fluorometric microculture cytotoxicity assay using a lymphoma cell line. The IC50 values ranged between 0.96 and 5.0 uM for vibi E, G and H, and vibi D was not cytotoxic at 30 uM. [...]
359 vibi H Cyclotide Viola biflora
Psychotria leptothyrsa
vibi D, E, G and H were analysed using fluorometric microculture cytotoxicity assay using a lymphoma cell line. The IC50 values ranged between 0.96 and 5.0 uM for vibi E, G and H, and vibi D was not cytotoxic at 30 uM. [...]
552 psyle A Cyclotide Psychotria leptothyrsa Psyle A, psyle C, psyle E and cycloviolacin O2 shown to possess cytotoxic activity in cancer cells. [...]
Nonclonogenic fluorometric microculture cytotoxicity assay was performed on psyle A, C and E using U-937 GTB human lymphoma tumor cell line. [...]
554 psyle C Cyclotide Psychotria leptothyrsa Psyle A, psyle C, psyle E and cycloviolacin O2 shown to possess cytotoxic activity in cancer cells. [...]
Nonclonogenic fluorometric microculture cytotoxicity assay was performed on psyle A, C and E using U-937 GTB human lymphoma tumor cell line. [...]
556 psyle E Cyclotide Psychotria leptothyrsa Nonclonogenic fluorometric microculture cytotoxicity assay was performed on psyle A, C and E using U-937 GTB human lymphoma tumor cell line. [...]
Psyle A, psyle C, psyle E and cycloviolacin O2 shown to possess cytotoxic activity in cancer cells. [...]
703 cyclolinopeptide A Orbitide Linum usitatissimum (flax) cyclolinopeptide A and B exhibited apoptosis induction on SGC-7901 cells. [...]
704 cyclolinopeptide B Orbitide Linum usitatissimum (flax) cyclolinopeptide A and B exhibited apoptosis induction on SGC-7901 cells. [...]
1217 DC1 Cyclotide Hedyotis diffusa DC1-3 demonstrated potent cytotoxicity in prostate cancer cells and DC3 had a lowest IC50 value. [...]
1218 DC2 Cyclotide Hedyotis diffusa DC1-3 demonstrated potent cytotoxicity in prostate cancer cells and DC3 had a lowest IC50 value. [...]
1220 DC3 Cyclotide Hedyotis diffusa DC1-3 demonstrated potent cytotoxicity in prostate cancer cells and DC3 had a lowest IC50 value. [...]
1308 Rivi1 Cyclotide Rinorea virgata Rivi1-4 showed cytotoxic activities against MDA-MB-231 (breast cancer), MM96L (melanoma), HT-29 (colon cancer), human umbilical vein endothelia cells (HUVECs) and HFF-1 (human foreskin fibroblast) cells. Rivil1 was the least toxic Rivi peptides, Rivi 2−4 had only slightly higher IC50 values than cycloviolacin O2 and showed minimal selectivity between the cell lines. Rivi1−3 did not show hemolytic activity. [...]
1309 Rivi2 Cyclotide Rinorea virgata Rivi1-4 showed cytotoxic activities against MDA-MB-231 (breast cancer), MM96L (melanoma), HT-29 (colon cancer), human umbilical vein endothelia cells (HUVECs) and HFF-1 (human foreskin fibroblast) cells. Rivil1 was the least toxic Rivi peptides, Rivi 2−4 had only slightly higher IC50 values than cycloviolacin O2 and showed minimal selectivity between the cell lines. Rivi1−3 did not show hemolytic activity. [...]
1310 Rivi3 Cyclotide Rinorea virgata Rivi1-4 showed cytotoxic activities against MDA-MB-231 (breast cancer), MM96L (melanoma), HT-29 (colon cancer), human umbilical vein endothelia cells (HUVECs) and HFF-1 (human foreskin fibroblast) cells. Rivil1 was the least toxic Rivi peptides, Rivi 2−4 had only slightly higher IC50 values than cycloviolacin O2 and showed minimal selectivity between the cell lines. Rivi1−3 did not show hemolytic activity. [...]
1311 Rivi4 Cyclotide Rinorea virgata Rivi1-4 showed cytotoxic activities against MDA-MB-231 (breast cancer), MM96L (melanoma), HT-29 (colon cancer), human umbilical vein endothelia cells (HUVECs) and HFF-1 (human foreskin fibroblast) cells. Rivil1 was the least toxic Rivi peptides, Rivi 2−4 had only slightly higher IC50 values than cycloviolacin O2 and showed minimal selectivity between the cell lines. Rivi1−3 did not show hemolytic activity. [...]
1313 Parigidin-br3 Cyclotide Palicourea rigida Parigidin-br3 showed cytotoxic activity against MCF-7 (breast cancer) and CACO2 (colorectal adenocarcinoma) cells, with IC50 values of ∼2.5 μM and less than 10% hemolytic activity. [...]
1321 HB5 Cyclotide Hedyotis biflora HB5-9 showed significant cytotoxicity on cancer cell lines BxPC3, Capan2, MOH1 and PANC1. HB7 inhibited the cell migration and invasion of Capan2 cells and could significantly inhibit the tumour weight and size. [...]
1322 HB6 Cyclotide Hedyotis biflora HB5-9 showed significant cytotoxicity on cancer cell lines BxPC3, Capan2, MOH1 and PANC1. HB7 inhibited the cell migration and invasion of Capan2 cells and could significantly inhibit the tumour weight and size. [...]
1323 HB7 Cyclotide Hedyotis biflora HB5-9 showed significant cytotoxicity on cancer cell lines BxPC3, Capan2, MOH1 and PANC1. HB7 inhibited the cell migration and invasion of Capan2 cells and could significantly inhibit the tumour weight and size. [...]
1324 HB8 Cyclotide Hedyotis biflora HB5-9 showed significant cytotoxicity on cancer cell lines BxPC3, Capan2, MOH1 and PANC1. HB7 inhibited the cell migration and invasion of Capan2 cells and could significantly inhibit the tumour weight and size. [...]
1325 HB9 Cyclotide Hedyotis biflora HB5-9 showed significant cytotoxicity on cancer cell lines BxPC3, Capan2, MOH1 and PANC1. HB7 inhibited the cell migration and invasion of Capan2 cells and could significantly inhibit the tumour weight and size. [...]