ID
Name
Class
Organism
Assay Summary
343
MCoTI-II[K10F]
Squash trypsin inhibitor
Synthetic
Synthetic MCoTI-I and MCoTI-II are both extremely potent trypsin inhibitors. [K10R] mutant has essentially wild-type activity against trypsin, whilst [K10F] and [K10Q] mutants are less active. [K10F] is the only mutant to show significant activity against chymotrypsin in this assay. [...]
342
MCoTI-II[K10Q]
Squash trypsin inhibitor
Synthetic
Synthetic MCoTI-I and MCoTI-II are both extremely potent trypsin inhibitors. [K10R] mutant has essentially wild-type activity against trypsin, whilst [K10F] and [K10Q] mutants are less active. [K10F] is the only mutant to show significant activity against chymotrypsin in this assay. [...]
341
MCoTI-II[K10R]
Squash trypsin inhibitor
Synthetic
Synthetic MCoTI-I and MCoTI-II are both extremely potent trypsin inhibitors. [K10R] mutant has essentially wild-type activity against trypsin, whilst [K10F] and [K10Q] mutants are less active. [K10F] is the only mutant to show significant activity against chymotrypsin in this assay. [...]
233
[AlaG10]oMCoTI-II
Squash trypsin inhibitor
Synthetic
Open chain variants have reduced inhibitory activity against bovine trypsin compared to native cyclic proteins. [...]
232
[R14]oMCoTI-II
Squash trypsin inhibitor
Synthetic
Open chain variants have reduced inhibitory activity against bovine trypsin compared to native cyclic proteins. [...]
231
[R13]oMCoTI-II
Squash trypsin inhibitor
Synthetic
Open chain variants have reduced inhibitory activity against bovine trypsin compared to native cyclic proteins. [...]
230
[R10]oMCoTI-II
Squash trypsin inhibitor
Synthetic
Open chain variants have reduced inhibitory activity against bovine trypsin compared to native cyclic proteins. [...]
229
[A14]oMCoTI-II
Squash trypsin inhibitor
Synthetic
Open chain variants have reduced inhibitory activity against bovine trypsin compared to native cyclic proteins. [...]
228
[A13]oMCoTI-II
Squash trypsin inhibitor
Synthetic
Open chain variants have reduced inhibitory activity against bovine trypsin compared to native cyclic proteins. [...]
227
[A10]oMCoTI-II
Squash trypsin inhibitor
Synthetic
Open chain variants have reduced inhibitory activity against bovine trypsin compared to native cyclic proteins. [...]
226
oMCoTI-II
Squash trypsin inhibitor
Synthetic
Open chain variants have reduced inhibitory activity against bovine trypsin compared to native cyclic proteins. [...]
219
SFTI-3
BBI-like trypsin inhibitor
Synthetic
Matriptase inhibitory activity of SFTI-2 is 25-fold less potent than native, while SFTI-3 exhibits similar potency. [...]
218
SFTI-2
BBI-like trypsin inhibitor
Synthetic
Matriptase inhibitory activity of SFTI-2 is 25-fold less potent than native, while SFTI-3 exhibits similar potency. [...]
217
[Ser3,11]aSFTI-1
BBI-like trypsin inhibitor
Synthetic
Disulfide bond is essenial for structure and function of acyclic SFTI-1. Seleno aSFTI-1 has 30% reduced inhibitory constant. [...]
216
Seleno aSFTI-1
BBI-like trypsin inhibitor
Synthetic
Disulfide bond is essenial for structure and function of acyclic SFTI-1. Seleno aSFTI-1 has 30% reduced inhibitory constant. [...]
215
[D14A]SFTI-1
BBI-like trypsin inhibitor
Synthetic
12 SFTI alanine mutants were tested for inhibitory activity against bovine trypsin. K5A mutant shows the weakest activity. [...]
214
[P13A]SFTI-1
BBI-like trypsin inhibitor
Synthetic
12 SFTI alanine mutants were tested for inhibitory activity against bovine trypsin. K5A mutant shows the weakest activity. [...]
213
[F12A]SFTI-1
BBI-like trypsin inhibitor
Synthetic
12 SFTI alanine mutants were tested for inhibitory activity against bovine trypsin. K5A mutant shows the weakest activity. [...]
212
[I10A]SFTI-1
BBI-like trypsin inhibitor
Synthetic
12 SFTI alanine mutants were tested for inhibitory activity against bovine trypsin. K5A mutant shows the weakest activity. [...]
211
[P9A]SFTI-1
BBI-like trypsin inhibitor
Synthetic
12 SFTI alanine mutants were tested for inhibitory activity against bovine trypsin. K5A mutant shows the weakest activity. [...]
210
[P8A]SFTI-1
BBI-like trypsin inhibitor
Synthetic
12 SFTI alanine mutants were tested for inhibitory activity against bovine trypsin. K5A mutant shows the weakest activity. [...]
209
[I7A]SFTI-1
BBI-like trypsin inhibitor
Synthetic
12 SFTI alanine mutants were tested for inhibitory activity against bovine trypsin. K5A mutant shows the weakest activity. [...]
208
[S6A]SFTI-1
BBI-like trypsin inhibitor
Synthetic
12 SFTI alanine mutants were tested for inhibitory activity against bovine trypsin. K5A mutant shows the weakest activity. [...]
207
[K5A]SFTI-1
BBI-like trypsin inhibitor
Synthetic
12 SFTI alanine mutants were tested for inhibitory activity against bovine trypsin. K5A mutant shows the weakest activity. [...]
206
[T4A]SFTI-1
BBI-like trypsin inhibitor
Synthetic
12 SFTI alanine mutants were tested for inhibitory activity against bovine trypsin. K5A mutant shows the weakest activity. [...]
205
[R2A]SFTI-1
BBI-like trypsin inhibitor
Synthetic
12 SFTI alanine mutants were tested for inhibitory activity against bovine trypsin. K5A mutant shows the weakest activity. [...]
204
[G1A]SFTI-1
BBI-like trypsin inhibitor
Synthetic
12 SFTI alanine mutants were tested for inhibitory activity against bovine trypsin. K5A mutant shows the weakest activity. [...]
203
[HmSer5]SFTI-1
BBI-like trypsin inhibitor
Synthetic
SFTI-1 and analogues shown to inhibit Bovine beta-trypsin and Human leukocyte elastase [...]
202
[(R)HmVal5]SFTI-1
BBI-like trypsin inhibitor
Synthetic
SFTI-1 and analogues shown to inhibit Bovine beta-trypsin and Human leukocyte elastase [...]
201
[(S)HmVal5]SFTI-1
BBI-like trypsin inhibitor
Synthetic
SFTI-1 and analogues shown to inhibit Bovine beta-trypsin and Human leukocyte elastase [...]
200
[(R,S)HmVal5]SFTI-1
BBI-like trypsin inhibitor
Synthetic
SFTI-1 and analogues shown to inhibit Bovine beta-trypsin and Human leukocyte elastase [...]
199
[Ser5]SFTI-1
BBI-like trypsin inhibitor
Synthetic
SFTI-1 and analogues shown to inhibit Bovine beta-trypsin and Human leukocyte elastase [...]
198
[Val5]SFTI-1
BBI-like trypsin inhibitor
Synthetic
SFTI-1 and analogues shown to inhibit Bovine beta-trypsin and Human leukocyte elastase [...]
196
HEI-TOS
BBI-like trypsin inhibitor
Synthetic
SFTI based variants shown to have activity against Porcine pancreatic elastase and Proteinase K [...]
195
OSFPKI III
BBI-like trypsin inhibitor
Synthetic
SFTI based variants shown to have activity against Porcine pancreatic elastase and Proteinase K [...]
193
OSFPKI I
BBI-like trypsin inhibitor
Synthetic
SFTI based variants shown to have activity against Porcine pancreatic elastase and Proteinase K [...]
194
OSFPKI II
BBI-like trypsin inhibitor
Synthetic
SFTI based variants shown to have activity against Porcine pancreatic elastase and Proteinase K [...]
192
OSFEI II
BBI-like trypsin inhibitor
Synthetic
SFTI based variants shown to have activity against Porcine pancreatic elastase and Proteinase K [...]
191
OSFEI I
BBI-like trypsin inhibitor
Synthetic
SFTI based variants shown to have activity against Porcine pancreatic elastase and Proteinase K [...]
137
MCoTI-I
Squash trypsin inhibitor
Momordica cochinchinensis
Open chain variants have reduced inhibitory activity against bovine trypsin compared to native cyclic proteins. [...]
112
PP-SFTI-13
BBI-like trypsin inhibitor
Synthetic
Ki calculated for a range of SFTI-1 analogues against trypsin and chymotrypsin. [...]
111
PP-SFTI-12
BBI-like trypsin inhibitor
Synthetic
Ki calculated for a range of SFTI-1 analogues against trypsin and chymotrypsin. [...]
110
PP-SFTI-11
BBI-like trypsin inhibitor
Synthetic
Ki calculated for a range of SFTI-1 analogues against trypsin and chymotrypsin. [...]
109
PP-SFTI-10
BBI-like trypsin inhibitor
Synthetic
Ki calculated for a range of SFTI-1 analogues against trypsin and chymotrypsin. [...]
108
PP-SFTI-9
BBI-like trypsin inhibitor
Synthetic
Ki calculated for a range of SFTI-1 analogues against trypsin and chymotrypsin. [...]
107
PP-SFTI-8
BBI-like trypsin inhibitor
Synthetic
Ki calculated for a range of SFTI-1 analogues against trypsin and chymotrypsin. [...]
106
PP-SFTI-7
BBI-like trypsin inhibitor
Synthetic
Ki calculated for a range of SFTI-1 analogues against trypsin and chymotrypsin. [...]
105
PP-SFTI-6
BBI-like trypsin inhibitor
Synthetic
Ki calculated for a range of SFTI-1 analogues against trypsin and chymotrypsin. [...]
104
PP-SFTI-5
BBI-like trypsin inhibitor
Synthetic
Ki calculated for a range of SFTI-1 analogues against trypsin and chymotrypsin. [...]
103
PP-SFTI-4
BBI-like trypsin inhibitor
Synthetic
Ki calculated for a range of SFTI-1 analogues against trypsin and chymotrypsin. [...]
102
PP-SFTI-3
BBI-like trypsin inhibitor
Synthetic
Ki calculated for a range of SFTI-1 analogues against trypsin and chymotrypsin. [...]
101
PP-SFTI-2
BBI-like trypsin inhibitor
Synthetic
Ki calculated for a range of SFTI-1 analogues against trypsin and chymotrypsin. [...]
100
[Nphe5]SFTI-1
BBI-like trypsin inhibitor
Synthetic
Chymotrypsin and trypsin Ka values determined for SFTI-1 analogues. [...]
99
[Nlys5]SFTI-1
BBI-like trypsin inhibitor
Synthetic
Chymotrypsin and trypsin Ka values determined for SFTI-1 analogues. [...]
98
[ABA3,11]SFTI-1[1,14]
BBI-like trypsin inhibitor
Synthetic
SFTI-1 analogues assayed for trypsin inhibitory activity. [...]
97
[ABA3,11]SFTI-1[6,5]
BBI-like trypsin inhibitor
Synthetic
SFTI-1 analogues assayed for trypsin inhibitory activity. [...]
96
BiKF
BBI-like trypsin inhibitor
Synthetic
Bifunctional analogues of SFTI-1 found to have trypsin and chymotrypsin inhibitory activity. [...]
95
BiKK
BBI-like trypsin inhibitor
Synthetic
Bifunctional analogues of SFTI-1 found to have trypsin and chymotrypsin inhibitory activity. [...]
93
[ABA3,11]SFTI-1
BBI-like trypsin inhibitor
Synthetic
SFTI-1 analogues assayed for trypsin inhibitory activity. [...] SFTI-1, an acyclic permutant and a [CYS-Abu]-cyclic mutant shown to possess potent trypsin inhibitory activity. [...]
81
SFTI-1
BBI-like trypsin inhibitor
Helianthus annus Helianthus exilis Helianthus tuberosus
Both SFTI-1 and acyclic SFTI-1 are potent inhibitors of bovine beta trypsin [...] SFTI-1 was found to have nano-molar inhibitory effect against matriptase and trypsin. [...] SFTI-1, an acyclic permutant and a [CYS-Abu]-cyclic mutant shown to possess potent trypsin inhibitory activity. [...] SFTI-1 immobilised on gold and interaction with trypsin investigated. [...] Bifunctional analogues of SFTI-1 found to have trypsin and chymotrypsin inhibitory activity. [...] Ki calculated for a range of SFTI-1 analogues against trypsin and chymotrypsin. [...] 12 SFTI alanine mutants were tested for inhibitory activity against bovine trypsin. K5A mutant shows the weakest activity. [...] Matriptase inhibitory activity of SFTI-2 is 25-fold less potent than native, while SFTI-3 exhibits similar potency. [...]
83
SFTI-1(6,5)
BBI-like trypsin inhibitor
Synthetic
SFTI-1(6,5) shown to have trypsin inhibitory activity and is cyclised after incubation with trypsin. [...]
82
N-SFTI-1-C
BBI-like trypsin inhibitor
Synthetic
Disulfide bond is essenial for structure and function of acyclic SFTI-1. Seleno aSFTI-1 has 30% reduced inhibitory constant. [...] SFTI-1 and analogues shown to inhibit Bovine beta-trypsin and Human leukocyte elastase [...] Chymotrypsin and trypsin Ka values determined for SFTI-1 analogues. [...] SFTI-1, an acyclic permutant and a [CYS-Abu]-cyclic mutant shown to possess potent trypsin inhibitory activity. [...] Both SFTI-1 and acyclic SFTI-1 are potent inhibitors of bovine beta trypsin [...]
4
kalata B2
Cyclotide
Oldenlandia affinis
Kalata B1 and B2 were found to have no trypsin or chymotrypsin inhibitory activity. [...]
3
MCoTI-II
Squash trypsin inhibitor
Momordica cochinchinensis
Open chain variants have reduced inhibitory activity against bovine trypsin compared to native cyclic proteins. [...]
1
kalata B1
Cyclotide
Viola odorata Oldenlandia affinis Viola tricolor Hybanthus enneaspermus Viola baoshanensis Viola yedoensis Viola philippica Viola sumatrana Miq
Kalata B1 and B2 were found to have no trypsin or chymotrypsin inhibitory activity. [...]