[ABA3,11]SFTI-1(93) Protein Card

General Information
Name [ABA3,11]SFTI-1
Sequence GRXTKSIPPIXFFD
Class BBI-like trypsin inhibitor
Average Mass 1580.27
Monoisotopic Mass 1579.27
m/z M+H 0
ProteinType Mutant
Parent SFTI-1
Organism Synthetic
Notes Cyclic SFTI-1 with alpha-aminobutiric acid substituted for Cys residues.
Cyclic Yes

Assay
Protease inhibition
SFTI-1, an acyclic permutant and a [CYS-Abu]-cyclic mutant shown to possess potent trypsin inhibitory activity. [...]Zablotna E et al. (2002) Biochem Biophys Res Commun 292:855-9
SFTI-1 analogues assayed for trypsin inhibitory activity. [...]Korsinczky ML et al. (2005) Biochemistry 44:1145-53

References
Zablotna E, Kazmierczak K, Jaskiewicz A, Stawikowski M, Kupryszewski G, Rolka K (2002) Chemical synthesis and kinetic study of the smallest naturally occurring trypsin inhibitor SFTI-1 isolated from sunflower seeds and its analogues. Biochem Biophys Res Commun 292:855-9
Korsinczky ML, Clark RJ, Craik DJ (2005) Disulfide bond mutagenesis and the structure and function of the head-to-tail macrocyclic trypsin inhibitor SFTI-1. Biochemistry 44:1145-53

Cross-references
Nucleic acids
Structure [ABA3,11]SFTI-1
Links

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