vibi H(359) Protein Card

General Information
Name vibi H
Sequence GLLPCAESCVYIPCLTTVIGCSCKSKVCYKN
Class Cyclotide
Average Mass 3272.93
Monoisotopic Mass 3270.51
m/z M+H 3271.52
ProteinType Wild type
Parent
Organism Viola biflora
Psychotria leptothyrsa
Notes
Cyclic Yes

Assay
Cancer Cell Toxicity
vibi D, E, G and H were analysed using fluorometric microculture cytotoxicity assay using a lymphoma cell line. The IC50 values ranged between 0.96 and 5.0 uM for vibi E, G and H, and vibi D was not cytotoxic at 30 uM. [...]Herrmann A et al. (2008) Phytochemistry 69:939-952

References
Herrmann A, Burman R, Mylne JS, Karlsson G, Gullbo J, Craik DJ, Clark RJ, Goransson U (2008) The alpine violet, Viola biflora, is a rich source of cyclotides with potent cytotoxicity Phytochemistry 69:939-952
Gerlach SL, Burman R, Bohlin L, Mondal D, Göransson U (2010) Isolation, characterization, and bioactivity of cyclotides from the Micronesian plant Psychotria leptothyrsa J Nat Prod 73:1207-1213

Cross-references
Nucleic acids
Structure
Links SwissProt P85246

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