cycloviolacin O8(27) Protein Card

General Information
Name cycloviolacin O8
Alternative name(s) Vaf/l-1
Sequence GTLPCGESCVWIPCISSVVGCSCKSKVCYKN
Class Cyclotide
Average Mass 3227.81
Monoisotopic Mass 3225.42
m/z M+H 3226.43
ProteinType Wild type
Parent
Organism Viola odorata
Viola adunca
Notes
Cyclic Yes

Assay
Nematocidal
A range of natural variants were selected based on net charge and/or hydrophobicity and were tested alongside the prototypic cyclotide kB1 in larval development assays with H. contortus and T. colubriformis. [...]Colgrave ML et al. (2008) Chembiochem 9:1939-1945

References
Dutton JL, Renda RF, Waine C, Clark RJ, Daly NL, Jennings CV, Anderson MA, Craik DJ (2004) Conserved structural and sequence elements implicated in the processing of gene-encoded circular proteins. J Biol Chem 279:46858-67
Craik DJ, Daly NL, Bond T, Waine C (1999) Plant cyclotides: A unique family of cyclic and knotted proteins that defines the cyclic cystine knot structural motif. J Mol Biol 294:1327-36
Ireland DC, Colgrave ML, Craik DJ (2006) A novel suite of cyclotides from Viola odorata: sequence variation and the implications for structure, function and stability. Biochem J. 400:1-12

Cross-references
Protein precursor(s) cyclotide c1 precursor
Val-1
Vaf-1
Nucleic acids cyclotide c1 precursor
Structure
Links GenBank P58440.2
SwissProt P58440

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