kalata B8(168) Protein Card

General Information
Name kalata B8
Sequence GSVLNCGETCLLGTCYTTGCTCNKYRVCTKD
Class Cyclotide
Technique MS,NGS,Amino acid analysis
Average Mass 3283.74
Monoisotopic Mass 3281.37
m/z M+H 3283.74
ProteinType Wild type
Parent
Organism Oldenlandia affinis
Hybanthus enneaspermus
Notes
Cyclic Yes

Assay
Hemolytic
Kalata B8 did not display haemolytic activity. [...]Daly NL et al. (2006) Biochem J 393:619-26
Anti-HIV
Kalata B8 showed anti-HIV and cytotoxic activity. Tricyclon A did not show anti-HIV or cytotoxic activity. [...]Daly NL et al. (2006) Biochem J 393:619-26
Chemical Shift
Chemical shift data for kalata B8 [...]
Molluscicidal
Cyclotides show molluscicidal activity [...]Plan MR et al. (2008) J Agric Food Chem 56:5237-5241

References
Daly NL, Clark RJ, Plan MR, Craik DJ (2006) Kalata B8, a novel antiviral circular protein, exhibits conformational flexibility in the cystine knot motif. Biochem J 393:619-26
Plan MR, Goransson U, Clark RJ, Daly NL, Colgrave ML, Craik DJ (2007) The Cyclotide Fingerprint in Oldenlandia affinis: Elucidation of Chemically Modified, Linear and Novel Macrocyclic Peptides Chembiochem 8:1001-1011
Du,Q., Chan,L.Y., Gilding,E.K., Henriques,S.T., Condon,N.D., Ravipati,A.S., Kaas,Q., Huang,Y.H. and Craik,D.J. (2020) Discovery and mechanistic studies of cytotoxic cyclotides from the medicinal herb <
i>
Hybanthus enneaspermus<
/i>
. J Biol Chem 295:10911-10925

Cross-references
Nucleic acids
Structure Solution structure of kalata B8
Links SwissProt P85175

Tools