kalata B8(168) Protein Card

General Information
Name kalata B8
Sequence GSVLNCGETCLLGTCYTTGCTCNKYRVCTKD
Class Cyclotide
Technique Amino acid analysis,MS
Average Mass 3283.74
Monoisotopic Mass 3281.37
m/z M+H 3283.74
ProteinType Wild type
Parent
Organism Oldenlandia affinis
Notes
Cyclic Yes

Assay
Molluscicidal
Cyclotides show molluscicidal activity [...]Plan MR et al. (2008) J Agric Food Chem 56:5237-5241
Chemical Shift
Chemical shift data for kalata B8 [...]
Anti-HIV
Kalata B8 showed anti-HIV and cytotoxic activity. Tricyclon A did not show anti-HIV or cytotoxic activity. [...]Daly NL et al. (2006) Biochem J 393:619-26
Hemolytic
Kalata B8 did not display haemolytic activity. [...]Daly NL et al. (2006) Biochem J 393:619-26

References
Daly NL, Clark RJ, Plan MR, Craik DJ (2006) Kalata B8, a novel antiviral circular protein, exhibits conformational flexibility in the cystine knot motif. Biochem J 393:619-26
Plan MR, Goransson U, Clark RJ, Daly NL, Colgrave ML, Craik DJ (2007) The Cyclotide Fingerprint in Oldenlandia affinis: Elucidation of Chemically Modified, Linear and Novel Macrocyclic Peptides Chembiochem 8:1001-1011

Cross-references
Nucleic acids
Structure Solution structure of kalata B8
Links SwissProt P85175

Tools