HB5(1321) Protein Card

General Information
Name HB5
Sequence GAVPCGESCVYLPCLTTVVGCSCQNSVCYHN
Class Cyclotide
Technique MS
Average Mass 3183.63
Monoisotopic Mass 3181.29
m/z M+H 3183.63
ProteinType Wild type
Parent
Organism Hedyotis biflora
Notes
Cyclic Yes

Assay
Cancer Cell Toxicity
HB5-9 showed significant cytotoxicity on cancer cell lines BxPC3, Capan2, MOH1 and PANC1. HB7 inhibited the cell migration and invasion of Capan2 cells and could significantly inhibit the tumour weight and size. [...]Ding et al. (2014) Medicinal Chemistry Research 23:1406-1413

References
Ding, X., Bai, D. and Qian, J (2014) Novel cyclotides from Hedyotis biflora inhibit proliferation and migration of pancreatic cancer cell in vitro and in vivo Medicinal Chemistry Research 23:1406-1413

Cross-references
Nucleic acids
Structure
Links

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