Rivi3(1310) Protein Card

General Information
Name Rivi3
Sequence GLPICGETCLLGKCYTPGCSCRRPVCYKN
Class Cyclotide
Technique MS,Amino acid analysis
Average Mass 3111.70
Monoisotopic Mass 3109.39
m/z M+H 3111.7
ProteinType Wild type
Parent
Organism Rinorea virgata
Notes
Cyclic Yes

Assay
Cancer Cell Toxicity
Rivi1-4 showed cytotoxic activities against MDA-MB-231 (breast cancer), MM96L (melanoma), HT-29 (colon cancer), human umbilical vein endothelia cells (HUVECs) and HFF-1 (human foreskin fibroblast) cells. Rivil1 was the least toxic Rivi peptides, Rivi 2−4 had only slightly higher IC50 values than cycloviolacin O2 and showed minimal selectivity between the cell lines. Rivi1−3 did not show hemolytic activity. [...]Niyomploy et al. (2018) Journal of natural products 81:2512-2520

References
Niyomploy, P., Chan, L.Y., Harvey, P.J., Poth, A.G., Colgrave, M.L. and Craik, D.J (2018) Discovery and characterization of cyclotides from Rinorea species Journal of natural products 81:2512-2520

Cross-references
Nucleic acids
Structure
Links

Tools