(102) Assay Card

General Information
Summary Cycloviolacin O13, O14 and O24 inhibited the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells with antiviral cytoprotective concentrations (EC50) of 320, 440, and 308 nM, while the cytotoxic concentration (IC50) was 6.4, 4.8, and 6.2 uM, respectively
Condition An in vitro XTT [2,3-bis-(2-methoxy-4-nitro-5-sulphophenyl)-2H-tetrazolium-5-carboxanilide]-based anti-HIV assay was used
Result Cycloviolacin O13, O14 and O24 inhibited the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells with antiviral cytoprotective concentrations (EC50) of 320, 440, and 308 nM, while the cytotoxic concentration (IC50) was 6.4, 4.8, and 6.2 uM, respectively
AssayType Anti-HIV

References
Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ (2008) Cyclotides as natural anti-HIV agents Biopolymers 90:51-60

Cross-references
Proteins Assayed cycloviolacin O13
cycloviolacin O24
cycloviolacin O14